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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Jaboticaba berry peel intake prevents insulin-resistance-induced tau phosphorylation in mice

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Autor(es):
Batista, Angela G. [1] ; Soares, Edilene S. [2] ; Mendonca, Monique C. P. [2, 3] ; da Silva, Juliana K. [1] ; Dionisio, Ana Paula [4] ; Sartori, Cesar R. [5] ; da Cruz-Hofling, Maria Alice [2, 3] ; Marostica Junior, Mario R. [1]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Univ Estadual Campinas, Fac Food Engn, Dept Food & Nutr, Campinas, SP - Brazil
[2] Univ Estadual Campinas, Inst Biol, Dept Biochem & Tissue Biol, Campinas, SP - Brazil
[3] Univ Estadual Campinas, Sch Med Sci, Dept Pharmacol, Campinas, SP - Brazil
[4] Brazilian Agr Res Corp, Embrapa Trop Agroind, Fortaleza, Ceara - Brazil
[5] Univ Estadual Campinas, Inst Biol, Dept Struct & Funct Biol, Campinas, SP - Brazil
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: MOLECULAR NUTRITION & FOOD RESEARCH; v. 61, n. 10 OCT 2017.
Citações Web of Science: 6
Resumo

The hyperphosphorylation of microtubule-associated protein tau (tau) in the hippocampus can be caused by central and peripheral insulin resistance and these alterations are related to the development of tauopathies, such as Alzheimer's disease. In this study, we used a high-fat diet to induce obesity and insulin resistance in adult Swiss mice and checked whether supplementation with Myrciaria jaboticaba berry peel for 10 weeks could improve insulin sensitivity, learning/memory performance, and prevent tau phosphorylation in the hippocampus. Furthermore, adipocytokines, inflammatory markers, and oxidative stress were assessed. Myrciaria jaboticaba peel has phenolic compounds (e.g., cyanidin, ellagic acid), dietary fiber and carotenoids, which contribute to great antioxidant capacity. Supplementation of the high-fat diet with 4% M. jaboticaba peel prevented fat weight gain and reduced peripheral insulin resistance. The treated group also showed lower tau phosphorylation in the hippocampus corroborating better learning/memory performance in the Morris water maze test. Maintenance of neuronal viability, lower levels of hippocampal inflammatory markers, and improved brain antioxidant defenses were also related to the consumption of M. jaboticaba peel. These findings contribute to a better understanding of how a high-fat diet supplemented with jaboticaba berry peel counteracts the impairment of cognitive functions caused by high-fat diet intake and diet-induced insulin resistance. (AU)

Processo FAPESP: 10/05262-5 - O efeito da casca de jabuticaba liofilizada, do ácido linoléico conjugado (CLA) e dos fitosteróis na prevenção e no tratamento da obesidade induzida por dieta hiperlipídica utilizando diferentes modelos experimentais
Beneficiário:Mário Roberto Maróstica Junior
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 15/50333-1 - Cobra: nova plataforma de descoberta de compostos para identificação rápida e de baixo custo de bioativo com efeitos benéficos originários de plantas brasileiras
Beneficiário:Glaucia Maria Pastore
Linha de fomento: Auxílio à Pesquisa - Temático