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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Evaluation of incidence, significance, and prognostic role of circulating tumor microemboli and transforming growth factor-beta receptor I in head and neck cancer

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Autor(es):
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Fanelli, Marcello Ferretti [1] ; Oliveira, Thiago Bueno [1] ; Braun, Alexcia Camila [2] ; Corassa, Marcelo [1, 2] ; Abdallah, Emne Ali [2] ; Nicolau, Ulisses Ribaldo [1] ; Alves, Vanessa da Silva [2] ; Garcia, Daniel [1] ; Calsavara, Vinicius F. [2] ; Kowalski, Luiz Paulo [3] ; Domingos Chinen, Ludmilla Thome [2]
Número total de Autores: 11
Afiliação do(s) autor(es):
[1] AC Camargo Canc Ctr, Dept Med Oncol, Sao Paulo, SP - Brazil
[2] AC Camargo Canc Ctr, Int Res Ctr, Rua Tagua 440, BR-01508010 Sao Paulo, SP - Brazil
[3] AC Camargo Canc Ctr, Dept Otolaryngol Head & Neck Surg, Sao Paulo, SP - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK; v. 39, n. 11, p. 2283-2292, NOV 2017.
Citações Web of Science: 10
Resumo

Background: Circulating tumor microemboli (CTM) are clusters of circulating tumor cells (CTCs), involved in metastasis, as also transforming growth factor-beta (TGF-beta). The purpose of this study was to verify their role in progression-free survival (PFS). Methods: Blood from patients with locally advanced head and neck squamous cell carcinoma (HNSCC; n553) was analyzed in 2 moments. TGF-beta receptor I (TGFbRI) expression was evaluated by immunocytochemistry. Results: Comparing CTM1 (baseline) with CTM2 (first follow-up), patients with CTM1-positive disease who became CTM2-negative were classified as favorable (PFS 20 months). Patients with unfavorable evolution (CTM1-negative/CTM2-positive), had PFS of 17.5 months. Patients always CTM-negative showed PFS of 22.4 months, those always positive, 4.7 months (P<. 001). The TGF-beta RI expression in the first follow-up correlated with poor PFS (12326 months; P5.007), being an independent prognostic factor (hazard ratio {[}HR] 56.088; P5.033). Conclusion: CTM1/2, TGF-beta RI expression, and unfavorable CTM kinetics may represent poor prognosis in locally advanced HNSCC. (AU)

Processo FAPESP: 13/08125-7 - Detecção de células tumorais circulantes e sua correlação com evolução clínica em carcinoma epidermóide de cabeça e pescoço
Beneficiário:Ludmilla Thomé Domingos Chinen
Linha de fomento: Auxílio à Pesquisa - Regular