Burkholderia cepacia complex in cystic fibrosis in... - BV FAPESP
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Burkholderia cepacia complex in cystic fibrosis in a Brazilian reference center

Texto completo
Autor(es):
Dentini, Priscila [1] ; Lima Marson, Fernando Augusto [1, 2] ; Bonadia, Luciana Cardoso [2] ; Bertuzzo, Carmen Silvia [2] ; Ribeiro, Antonio Fernando [1] ; Levy, Carlos Emilio [3] ; Ribeiro, Jose Dirceu [1]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Estadual Campinas, Sch Med Sci, Dept Pediat, POB 6111, BR-13081970 Campinas, SP - Brazil
[2] Univ Estadual Campinas, Sch Med Sci, Dept Med Genet, POB 6111, BR-13081970 Campinas, SP - Brazil
[3] Univ Estadual Campinas, Sch Med Sci, Dept Clin Pathol, POB 6111, BR-13081970 Campinas, SP - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: MEDICAL MICROBIOLOGY AND IMMUNOLOGY; v. 206, n. 6, p. 447-461, DEC 2017.
Citações Web of Science: 0
Resumo

The Burkholderia cepacia complex (BCC) can cause a severe decline in lung function in cystic fibrosis (CF). Our objective was to determine the BCC prevalence and to evaluate its clinical impact on CF. Clinical and laboratory variables were determined for CF patients with BCC (Group-A = 50 patients) and without BCC (Group-B = 134 patients). The microorganisms were identified by biochemical tests, the Vitek2(A (R))Compact test, recA-PCR and recA-nested-PCR with species-specific primers and DNA sequencing. The patients were evaluated by the Shwachman-Kulczycki score (SKCS), Bhalla score (BS), spirometry and body mass index (BMI). The BCC prevalence was 22.5%. The most common species were Burkholderia multivorans (30%), Burkholderia cepacia (24%), Burkholderia cenocepacia IIIA (10%), B. cenocepacia IIIB (2%) and Burkholderia vietnamiensis (2%). There was difference between the groups in nutritional status (p = 0.02) and general activity (p = 0.026). There was difference in total BS points (p = 0.04) and the following parameters: bronchiectasis severity (p = 0.007), peribronchial thickening (p = 0.013), bronchiectasis extent (p = 0.01) and general aspects of the affected bronchial zone (p = 0.02). The respiratory disorder classifications were as follows: obstructive-4.8% (Group-A) and 23.8% (Group-B); restrictive-9.5% (Group-A and Group-B); obstructive + restrictive-19% (Group-A) and 1.6% (Group-B); and obstructive + restrictive with a decreased forced expiratory flow-47.6% (Group-A) and 30.2% (Group-B) (p = 0.02). Nutritional status was a minor contributing factor to weight, height and BMI in the Group-A (p = 0.02). The BCC prevalence, particularly the prevalence of B. multivorans, was higher in this study. The SKCS, BS, spirometry and nutritional status results showed that BCC has a negative impact on clinical status. Phenotypic methods are useful for the identification of presumptive BCC. The Vitek2(A (R))Compact test showed accuracy in BCC identification. PCR, nested-PCR, and recA sequencing showed specificity in BCC species identification. (AU)

Processo FAPESP: 11/12939-4 - Associação entre polimorfismos de genes moduladores em crianças e adolescentes com asma alérgica e não alérgica: leve, moderada e grave
Beneficiário:Fernando Augusto de Lima Marson
Modalidade de apoio: Bolsas no Brasil - Doutorado
Processo FAPESP: 15/12858-5 - Identificação das mutações prevalentes e caracterização clínica e funcional de crianças e adultos com discinesia ciliar primária
Beneficiário:Fernando Augusto de Lima Marson
Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 15/12183-8 - Identificação das mutações prevalentes e caracterização clínica e funcional de crianças e adultos com discinesia ciliar primária
Beneficiário:Jose Dirceu Ribeiro
Modalidade de apoio: Auxílio à Pesquisa - Regular
Processo FAPESP: 11/18845-1 - Associação entre polimorfismos de genes moduladores em crianças e adolescentes com asma alérgica e não alérgica leve, moderada e grave
Beneficiário:Jose Dirceu Ribeiro
Modalidade de apoio: Auxílio à Pesquisa - Regular