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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Advances in Hybrid Polymer-Based Materials for Sustained Drug Release

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Autor(es):
Ribeiro, Ligia N. M. [1] ; Alcantara, Ana C. S. [2] ; Rodrigues da Silva, Gustavo H. [1] ; Franz-Montan, Michelle [3] ; Nista, Silvia V. G. [4] ; Castro, Simone R. [1] ; Couto, Veronica M. [1] ; Guilherme, Viviane A. [1] ; de Paula, Eneida [1]
Número total de Autores: 9
Afiliação do(s) autor(es):
[1] Univ Estadual Campinas, Biol Inst, Dept Biochem & Tissue Biol, BR-13083862 Campinas, SP - Brazil
[2] Univ Fed Maranhao, Dept Chem, BR-65080805 Sao Luis, MA - Brazil
[3] Univ Estadual Campinas, Piracicaba Dent Sch, Dept Physiol Sci, BR-13414903 Piracicaba, SP - Brazil
[4] Univ Estadual Campinas, Sch Chem Engn, Dept Mat & Bioproc Engn, BR-13083852 Campinas, SP - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo de Revisão
Fonte: INTERNATIONAL JOURNAL OF POLYMER SCIENCE; 2017.
Citações Web of Science: 4
Resumo

The use of biomaterials composed of organic pristine components has been successfully described in several purposes, such as tissue engineering and drug delivery. Drug delivery systems (DDS) have shown several advantages over traditional drug therapy, such as greater therapeutic efficacy, prolonged delivery profile, and reduced drug toxicity, as evidenced by in vitro and in vivo studies as well as clinical trials. Despite that, there is no perfect delivery carrier, and issues such as undesirable viscosity and physicochemical stability or inability to efficiently encapsulate hydrophilic/hydrophobic molecules still persist, limiting DDS applications. To overcome that, biohybrid systems, originating from the synergistic assembly of polymers and other organic materials such as proteins and lipids, have recently been described, yielding molecularly planned biohybrid systems that are able to optimize structures to easily interact with the targets. This work revised the biohybrid DDS clarifying their advantages, limitations, and future perspectives in an attempt to contribute to further research of innovative and safe biohybrid polymer-based system as biomaterials for the sustained release of active molecules. (AU)

Processo FAPESP: 14/25372-0 - Desenvolvimento de carreadores lipídicos nanoestruturados para encapsulação de anestésicos locais processados em matrizes biopoliméricas para aplicação tópica em mucosa oral
Beneficiário:Lígia Nunes de Morais Ribeiro
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 14/14457-5 - Carreadores baseados em lipídios (SLN/NLC e lipossomas com gradiente iônico) como estratégia para aumentar a encapsulação e a potência de anestésicos locais
Beneficiário:Eneida de Paula
Linha de fomento: Auxílio à Pesquisa - Temático