Personality measures after gamma ventral capsulotomy in intractable OCD

Autor(es):Mostrar menos -

Paiva, Raquel R. ^{[1, 2]} ; Batistuzzo, Marcelo C. ^[1] ; McLaughlin, Nicole C. ^[3] ; Canteras, Miguel M. ^[4] ; de Mathis, Maria E. ^[1] ; Requena, Guaraci ^[1] ; Shavitt, Roseli G. ^[1] ; Greenberg, Benjamin D. ^{[3, 5]} ; Noren, Georg ^[6] ; Rasmussen, Steven A. ^[3] ; Tavares, Hermano ^[1] ; Miguel, Euripedes C. ^[1] ; Lopes, Antonio C. ^[1] ; Hoexter, Marcelo Q. ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Hosp Clin HCFMUSP, Dept & Inst Psychiat, Fac Med, Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med, Sao Paulo, SP - Brazil

^[3] Brown Univ, Dept Psychiat & Human Behav, Butler Hosp, Warren Alpert Med Sch, Providence, RI 02912 - USA

^[4] Hosp Santa Paula, Inst Neurol Radiosurg, Sao Paulo - Brazil

^[5] Providence VA Med Ctr, Ctr Neurorestorat & Neurol, Providence, RI - USA

^[6] Brown Univ, Dept Neurosurg, Warren Alpert Med Sch, Providence, RI 02912 - USA

• Tipo de documento: Artigo Científico
• Fonte: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY; v. 81, p. 161-168, FEB 2 2018.
• Citações Web of Science: 2

Resumo

Background: Neurosurgeries such as gamma ventral capsulotomy (GVC) are an option for otherwise intractable obsessive-compulsive disorder (OCD) patients. In general, clinical and neuropsychological status both improve after GVC. However, its consequences on personality traits are not well-studied. The objective of this study was to investigate personality changes after one year of GVC in intractable OCD patients. Methods: The personality assessment was conducted using the Revised NEO Personality Inventory (NEO PI-R) and Cloninger's Temperament and Character Inventory (TCI) in 14 intractable OCD patients before and one year after GVC. Comparisons of personality features between treatment responders (n = 5) and non-responders (n = 9) were performed. Multiple linear regression was also used for predicting changes in clinical and global functioning variables. Results: Overall, no deleterious effect was found in personality after GVC. Responders had a reduction in neuroticism (p = 0.043) and an increase in extraversion (p = 0.043). No significant changes were observed in nonresponders. Increases in novelty seeking and self-directedness, and decreases in persistence and cooperativiness predicted OCD symptom improvement. Similary, improvement in functioning was also predicted by hgher novelty seeking and self-directedness after GVC, whereas better functioning was also associated with lower reward dependence and cooperativeness after surgery. Conclusions: The pattern of changes in personality traits after GVC was generally towards that observed in nonclinical population, and does not raise safety concerns. (AU)

• Processo FAPESP: 11/21357-9 - Investigação de circuitos neuronais e marcadores biológicos envolvidos no transtorno obsessivo-compulsivo por meio de paradigmas comportamentais de medo e ansiedade
• Beneficiário: Eurípedes Constantino Miguel Filho
• Linha de fomento: Auxílio à Pesquisa - Temático
• Processo FAPESP: 13/16864-4 - Capsulotomia ventral por raios gama com lesões únicas bilaterais e estimulação encefálica profunda no TOC: avaliação da eficácia, eventos adversos e alterações no funcionamento cerebral
• Beneficiário: Marcelo Queiroz Hoexter
• Linha de fomento: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 16/05865-8 - Níveis de metabólitos no córtex pré-frontal ventromedial em pacientes com transtorno obsessivo-compulsivo: um estudo de espectroscopia de prótons por ressonância magnética
• Beneficiário: Marcelo Camargo Batistuzzo
• Linha de fomento: Bolsas no Brasil - Pós-Doutorado