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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Personality measures after gamma ventral capsulotomy in intractable OCD

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Autor(es):
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Paiva, Raquel R. [1, 2] ; Batistuzzo, Marcelo C. [1] ; McLaughlin, Nicole C. [3] ; Canteras, Miguel M. [4] ; de Mathis, Maria E. [1] ; Requena, Guaraci [1] ; Shavitt, Roseli G. [1] ; Greenberg, Benjamin D. [3, 5] ; Noren, Georg [6] ; Rasmussen, Steven A. [3] ; Tavares, Hermano [1] ; Miguel, Euripedes C. [1] ; Lopes, Antonio C. [1] ; Hoexter, Marcelo Q. [1, 2]
Número total de Autores: 14
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Hosp Clin HCFMUSP, Dept & Inst Psychiat, Fac Med, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med, Sao Paulo, SP - Brazil
[3] Brown Univ, Dept Psychiat & Human Behav, Butler Hosp, Warren Alpert Med Sch, Providence, RI 02912 - USA
[4] Hosp Santa Paula, Inst Neurol Radiosurg, Sao Paulo - Brazil
[5] Providence VA Med Ctr, Ctr Neurorestorat & Neurol, Providence, RI - USA
[6] Brown Univ, Dept Neurosurg, Warren Alpert Med Sch, Providence, RI 02912 - USA
Número total de Afiliações: 6
Tipo de documento: Artigo Científico
Fonte: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY; v. 81, p. 161-168, FEB 2 2018.
Citações Web of Science: 2
Resumo

Background: Neurosurgeries such as gamma ventral capsulotomy (GVC) are an option for otherwise intractable obsessive-compulsive disorder (OCD) patients. In general, clinical and neuropsychological status both improve after GVC. However, its consequences on personality traits are not well-studied. The objective of this study was to investigate personality changes after one year of GVC in intractable OCD patients. Methods: The personality assessment was conducted using the Revised NEO Personality Inventory (NEO PI-R) and Cloninger's Temperament and Character Inventory (TCI) in 14 intractable OCD patients before and one year after GVC. Comparisons of personality features between treatment responders (n = 5) and non-responders (n = 9) were performed. Multiple linear regression was also used for predicting changes in clinical and global functioning variables. Results: Overall, no deleterious effect was found in personality after GVC. Responders had a reduction in neuroticism (p = 0.043) and an increase in extraversion (p = 0.043). No significant changes were observed in nonresponders. Increases in novelty seeking and self-directedness, and decreases in persistence and cooperativiness predicted OCD symptom improvement. Similary, improvement in functioning was also predicted by hgher novelty seeking and self-directedness after GVC, whereas better functioning was also associated with lower reward dependence and cooperativeness after surgery. Conclusions: The pattern of changes in personality traits after GVC was generally towards that observed in nonclinical population, and does not raise safety concerns. (AU)

Processo FAPESP: 11/21357-9 - Investigação de circuitos neuronais e marcadores biológicos envolvidos no transtorno obsessivo-compulsivo por meio de paradigmas comportamentais de medo e ansiedade
Beneficiário:Eurípedes Constantino Miguel Filho
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 13/16864-4 - Capsulotomia ventral por raios gama com lesões únicas bilaterais e estimulação encefálica profunda no TOC: avaliação da eficácia, eventos adversos e alterações no funcionamento cerebral
Beneficiário:Marcelo Queiroz Hoexter
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 16/05865-8 - Níveis de metabólitos no córtex pré-frontal ventromedial em pacientes com transtorno obsessivo-compulsivo: um estudo de espectroscopia de prótons por ressonância magnética
Beneficiário:Marcelo Camargo Batistuzzo
Linha de fomento: Bolsas no Brasil - Pós-Doutorado