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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Biosurfactants produced by Scheffersomyces stipitis cultured in sugarcane bagasse hydrolysate as new green larvicides for the control of Aedes aegypti, a vector of neglected tropical diseases

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Autor(es):
Franco Marcelino, Paulo Ricardo [1] ; da Silva, Vinicius Luiz [2] ; Philippini, Rafael Rodrigues [1] ; Von Zuben, Claudio Jose [3] ; Contiero, Jonas [2] ; dos Santos, Julio Cesar [1] ; da Silva, Silvio Silverio [1]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Engn Sch Lorena, Dept Biotechnol, Lorena - Brazil
[2] Sao Paulo State Univ, Dept Biochem & Microbiol, Biosci Inst, Campus Rio Claro, Rio Claro - Brazil
[3] Sao Paulo State Univ, Dept Zool, Biosci Inst, Campus Rio Claro, Rio Claro - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: PLoS One; v. 12, n. 11 NOV 10 2017.
Citações Web of Science: 4
Resumo

Biosurfactants are microbial metabolites with possible applications in various industrial sectors that are considered ecofriendly molecules. In recent years, some studies identified these compounds as alternatives for the elimination of vectors of tropical diseases, such as Aedes aegypti. The major bottlenecks of biosurfactant industrial production have been the use of conventional raw materials that increase production costs as well as opportunistic or pathogenic bacteria, which restrict the application of these biomolecules. The present study shows the potential of hemicellulosic sugarcane bagasse hydrolysate as a raw material for the production of a crystalline glycolipidic BS by Scheffersomyces stipitis NRRL Y-7124, which resulted in an emulsifying index (EI24) of 70 +/- 3.4% and a superficial tension of 52 +/- 2.9 mN.m(-1). Additionally, a possible new application of these compounds as biolarvicides, mainly against A. aegypti, was evaluated. At a concentration of 800 mg.L-1, the produced biosurfactant caused destruction to the larval exoskeletons 12 h after application and presented an letal concentration (LC50) of 660 mg.L-1. Thus, a new alternative for biosurfactant production using vegetal biomass as raw material within the concept of biorefineries was proposed, and the potential of the crystalline glycolipidic biosurfactant in larvicidal formulations against neglected tropical disease vectors was demonstrated. (AU)

Processo FAPESP: 15/06238-4 - Biossurfactantes como moléculas versáteis: um novo conceito de produtos para biorrefinarias e combate às doenças tropicais negligenciadas fase 1: seleção de leveduras, produção fermentativa e caracterização físico-química
Beneficiário:Silvio Silvério da Silva
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 16/14852-7 - Uma solução sustentável contra doenças tropicais negligenciadas utilizando biossurfactantes produzidos por leveduras em hidrolisado hemicelulósico de bagaço de cana-de-açúcar
Beneficiário:Paulo Ricardo Franco Marcelino
Linha de fomento: Bolsas no Brasil - Pós-Doutorado