Genomic and epidemiological characterisation of a dengue virus outbreak among blood donors in Brazil

Autor(es):Mostrar menos -

Faria, Nuno R. ^[1] ; da Costa, Antonio Charlys ^{[2, 3]} ; Lourenco, Jose ^[1] ; Loureiro, Paula ^[4] ; Lopes, Maria Esther ^[5] ; Ribeiro, Roberto ^{[2, 3]} ; Alencar, Cecilia Salete ^[6] ; Kraemer, Moritz U. G. ^[1] ; Villabona-Arenas, Christian J. ^[7] ; Wu, Chieh-Hsi ^[8] ; Theze, Julien ^[1] ; Khan, Kamran ^{[9, 10]} ; Brent, Shannon E. ^[9] ; Romano, Camila ^[2] ; Delwart, Eric ^{[11, 12]} ; Custer, Brian ^{[11, 12]} ; Busch, Michael P. ^{[11, 12]} ; Pybus, Oliver G. ^[1] ; Sabino, Ester C. ^{[2, 3]} ; Epidemiology, NHLBI Recipient ; Study, Donor Evaluation

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^[1] Univ Oxford, Dept Zool, Oxford - England

^[2] Univ Sao Paulo, Inst Med Trop, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Fac Med, Dept Molestias Infecciosas & Parasitarias, LIM46, Sao Paulo - Brazil

^[4] Fundacao Hemope, Fac Ciencias Med, Recife, PE - Brazil

^[5] Fundacao Hemorio, Rio De Janeiro - Brazil

^[6] Hosp Clin Sao Paulo, Lab Invest Med LIM03, Sao Paulo - Brazil

^[7] Univ Montpellier, Inst Rech Dev, Montpellier - France

^[8] Univ Oxford, Dept Stat, Oxford - England

^[9] St Michaels Hosp, Li Ka Shing Knowledge Inst, Toronto, ON - Canada

^[10] Univ Toronto, Div Infect Dis, Toronto, ON - Canada

^[11] Blood Syst Res Inst, San Francisco, CA - USA

^[12] Univ Calif San Francisco, San Francisco, CA 94143 - USA

• Tipo de documento: Artigo Científico
• Fonte: SCIENTIFIC REPORTS; v. 7, NOV 9 2017.
• Citações Web of Science: 12

Resumo

Outbreaks caused by Dengue, Zika and Chikungunya viruses can spread rapidly in immunologically naive populations. By analysing 92 newly generated viral genome sequences from blood donors and recipients, we assess the dynamics of dengue virus serotype 4 during the 2012 outbreak in Rio de Janeiro. Phylogenetic analysis indicates that the outbreak was caused by genotype II, although two isolates of genotype I were also detected for the first time in Rio de Janeiro. Evolutionary analysis and modelling estimates are congruent, indicating a reproduction number above 1 between January and June, and at least two thirds of infections being unnoticed. Modelling analysis suggests that viral transmission started in early January, which is consistent with multiple introductions, most likely from the northern states of Brazil, and with an increase in within-country air travel to Rio de Janeiro. The combination of genetic and epidemiological data from blood donor banks may be useful to anticipate epidemic spread of arboviruses. (AU)

• Processo FAPESP: 16/01735-2 - Metagenômica viral de Dengue, Chikungunya e Zika vírus: Acompanhar, explicar e prever a transmissão e distribuição espaço-temporal no Brasil.
• Beneficiário: Ester Cerdeira Sabino
• Linha de fomento: Auxílio à Pesquisa - Regular
• Processo FAPESP: 11/18955-1 - Prevalência de dengue em doadores e receptores de sangue brasileiros: índice de transmissão por transfusão e resultados clínicos de infecção por dengue em receptores
• Beneficiário: Ester Cerdeira Sabino
• Linha de fomento: Auxílio à Pesquisa - Regular
• Processo FAPESP: 17/00021-9 - Metagenômica viral da Dengue, Chikungunya e Zika: Acompanhar, explicar e prever a transmissão e distribuição espaço-temporal no Brasil
• Beneficiário: Antonio Charlys da Costa
• Linha de fomento: Bolsas no Brasil - Pós-Doutorado