Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Outbreak of chikungunya virus in a vulnerable population of Sergipe, Brazil-A molecular and serological survey

Texto completo
Autor(es):
Cunha, Marielton dos Passos [1] ; dos Santos, Cliomar Alves [2] ; de Lima Neto, Daniel Ferreira [1] ; Schanoski, Alessandra Soares [3] ; Pour, Shahab Zaki [1] ; Passos, Saulo Duarte [4] ; Feitosa de Souzae, Mercia Simone [5] ; Costa, Danuza Duarte [2] ; de Andrade Zanotto, Paolo Marinho [1]
Número total de Autores: 9
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Biomed Sci Inst, Dept Microbiol, Lab Mol Evolut & Bioinformat, Sao Paulo - Brazil
[2] State Secretary Hlth, Cent Lab Publ Hlth LACEN SE, Hlth Fdn Parreiras Horta FSPH, Sergipe - Brazil
[3] Butantan Inst, Bacteriol Lab 2, Sao Paulo - Brazil
[4] Jundiai Med Fac, Dept Pediat, Sao Paulo - Brazil
[5] State Secretary Hlth, Coordinat Nucleus Communicable Dis, Sergipe - Brazil
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: Journal of Clinical Virology; v. 97, p. 44-49, DEC 2017.
Citações Web of Science: 9
Resumo

Background: Chikungunya virus (CHIKV) is a re-emerging arbovirus that is causing outbreaks in several countries of the Americas. The virus was introduced in Brazil in 2014, and since then, several Brazilian states have notified autochthonous cases. Objectives: Provide additional evidence on a CHIKV outbreak and an outline of the laboratory and clinical profile of symptomatic patients in Sergipe, Brazil. Study design: In February 2016, we collected 142 serum samples from symptomatic patients for arboviruses in Sergipe, Brazil. All samples were submitted to qRT-PCR for the emerging arboviruses circulating in Brazil - ZIKV, CHIKV, and DENV - and later submitted to the immunoenzymatic assay. RNA positive samples were randomly selected and sequenced for characterization of the genotype involved in the outbreak. Results: Our study had 75.35% (107/142) positivity for CHIKV infection, with all age groups and genera being equally infected. The virus was identified in 11 of the 13 cities studied in that state, including the ECSA genotype. Importantly, fever was the only statistically significant symptoms for CHIKV infection (p < 0.05), while asthenia was significantly associated with symptomatic patients that were CHIKV-negative (p < 0.05). Conclusions: Our findings support the importance of fever as a clinical marker and contribute to molecular and serological surveillance data, which may help in the understanding of CHIKV circulation, emergence and clinical description. (AU)

Processo FAPESP: 14/17766-9 - Abordagem sistêmica no estudo da permissividade do Anticarsia gemmatalis múltiplo nucleopoliedrovírus (AgMNPV)
Beneficiário:Paolo Marinho de Andrade Zanotto
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 16/08204-2 - Diversidade genética e filodinâmica dos arbovírus emergentes e reemergentes (DENV, ZIKV e CHIKV) nas regiões Nordeste e Sudeste do Brasil, 2014-2016
Beneficiário:Marielton dos Passos Cunha
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 16/03605-9 - Expressão temporal dos genes do Zika vírus das linhagens africana e brasileira e mapeamento da expressão gênica em sistemas permissivos, semi-permissivos e não permissivos
Beneficiário:Daniel Ferreira de Lima Neto
Linha de fomento: Bolsas no Brasil - Pós-Doutorado