Histological analysis of the repair of dural lesions with silicone mesh in rats subjected to experimental lesions

Autor(es)

Figueiredo da Rosa, Fernando William ^[1] ; Isoldi Pohl, Pedro Henrique ^[1] ; Amaral Antonio Mader, Ana Maria ^[1] ; de Paiva, Carla Peluso ^[1] ; dos Santos, Aline Amaro ^[1] ; Bianco, Bianca ^[1] ; Reis Rodrigues, Luciano Miller ^[1]

Afiliação do(s) autor(es)

^[1] Fac Med ABC, Santo Andre, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Einstein (São Paulo); v. 13, n. 4, p. 567-573, OCT-DEC 2015.
• Citações Web of Science: 0

Resumo

Objective: To evaluate inflammatory reaction, fibrosis and neovascularization in dural repairs in Wistar rats using four techniques: simple suture, bovine collagen membrane, silicon mesh and silicon mesh with suture. Methods: Thirty Wistar rats were randomized in five groups: the first was the control group, submitted to dural tear only. The others underwent durotomy and simple suture, bovine collagen membrane, silicon mesh and silicon mesh with suture. Animals were euthanized and the spine was submitted to histological evaluation with a score system (ranging from zero to 3) for inflammation, neovascularization and fibrosis. Results: Fibrosis was significantly different between simple suture and silicon mesh (p= 0.005) and between simple suture and mesh with suture (p= 0.015), showing that fibrosis is more intense when a foreign body is used in the repair. Bovine membrane was significantly different from mesh plus suture (p= 0.011) regarding vascularization. Inflammation was significantly different between simple suture and bovine collagen membrane. Conclusion: Silicon mesh, compared to other commercial products available, is a possible alternative for dural repair. More studies are necessary to confirm these findings. (AU)

• Processo FAPESP: 13/00902-4 - Avaliação da frequência de polimorfismos do gene do receptor da Vitamina D (VDR) como fator de risco na etiologia da degeneração discal
• Beneficiário: Luciano Miller Reis Rodrigues
• Modalidade de apoio: Auxílio à Pesquisa - Regular