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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Characterization of the Effects of the Shiitake Culinary-Medicinal Mushroom, Lentinus edodes (Agaricomycetes), on Severe Gestational Diabetes Mellitus in Rats

Texto completo
Autor(es):
Maschio, Bianca Hessel [1, 2] ; Gentil, Bianca Carvalho [2] ; Ajala Caetano, Erika Leao [1, 2] ; Rodrigues, Lucas Silva [2] ; Laurino, Leticia Favara [1, 2] ; Vieira Spim, Sara Rosicler [1, 2] ; Jozala, Angela Faustino [2, 3] ; dos Santos, Carolina Alves [1] ; Grotto, Denise [1, 2, 3] ; Gerenutti, Marli [1, 2, 3]
Número total de Autores: 10
Afiliação do(s) autor(es):
[1] Univ Sorocaba, Dept Dev & Evaluat Bioact Subst, Post Grad Program Pharmaceut Sci, Rodovia Raposo Tavares Km 92-5, BR-18023000 Sorocaba, SP - Brazil
[2] Univ Sorocaba, UNISO, Lab Toxicol Res Lapetox, Sorocaba, SP - Brazil
[3] Univ Sorocaba, UNISO, Dept Technol & Environm Proc, Sorocaba, SP - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: International Journal of Medicinal Mushrooms; v. 19, n. 11, p. 991-1000, 2017.
Citações Web of Science: 3
Resumo

This study evaluated the protective effect of Lentinus edodes in rats with streptozotocin-induced gestational diabetes mellitus (STZ-GDM) when administered orally. The rats received from the 1st to the 19th day of gestation daily doses of 100 or 200 mg/kg of lyophilized and reconstituted L. edodes; the animals in the saline control group and diabetic control group received a saline solution (DS). Gestational diabetes mellitus was induced by streptozotocin (80 mg/kg, administered intraperitoneally) on the fourth day of pregnancy; blood glucose > 180 mg/dL was considered to indicate STZ-GDM. L. edodes reduced catalase in plasma. We also observed reduced glucose in plasma, urea, triglycerides, and aspartate aminotransferase. There was a decrease in preimplantation loss when compared with the DS group. The doses of L. edodes used here had a protective effect on the preimplantation parameters in STZ-GDM. However, the mushroom was not able to reverse the deleterious effects caused by streptozotocin throughout the evolution of pregnancy. (AU)

Processo FAPESP: 15/24566-9 - Ensaios pré-clínicos com os cogumelos Agaricus blazei, Lentinula edodes e Ganoderma lucidum, visando à redução de danos maternos e fetais causados pelo diabetes gestacional
Beneficiário:Marli Gerenutti
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 13/05765-5 - Avaliação de parâmetros bioquímicos e antioxidantes em ratos expostos ao Lentinula edodes (shiitake), e seu possível uso em distúrbios metabólicos
Beneficiário:Denise Grotto
Linha de fomento: Auxílio à Pesquisa - Regular