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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Chrysin Administration Protects against Oxidative Damage in Varicocele-Induced Adult Rats

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Autor(es):
Missassi, Gabriela [1, 2] ; Borges, Cibele dos Santos [1] ; Rosa, Josiane de Lima [1] ; Villela e Silva, Patricia [1] ; Martins, Jr., Airton da Cunha [3] ; Barbosa, Jr., Fernando [3] ; Kempinas, Wilma De Grava [1]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Sao Paulo State Univ UNESP, Inst Biosci, Dept Morphol, Botucatu, SP - Brazil
[2] Univ Campinas UNICAMP, Grad Program Cell & Struct Biol, Campinas, SP - Brazil
[3] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Dept Clin Analyses Toxicol & Food Sci, Ribeirao Preto, SP - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: OXIDATIVE MEDICINE AND CELLULAR LONGEVITY; 2017.
Citações Web of Science: 1
Resumo

Oxidative stress is known as the leading factor responsible for varicocele-related infertility and for that reason, many antioxidant therapies have been proposed. Considering that, we evaluated the reproductive outcomes and fertility of varicocelized rats and the impact of chrysin within these parameters. The animals were allocated into three groups: sham (control), varicocele treated via gavage with 50 mg/kg/day of chrysin (V1), or vehicle (V2) for 56 days. Chrysin treatment prevented oxidative damage resulting from varicocele by decreasing testicular concentrations of malondialdehyde and sperm DNA fragmentation. It also improved histological aspect of the testis and maintained morphometric parameters similar to the sham group. Furthermore, there were no differences in body and reproductive organ weights, histopathological analysis of epididymis, sperm counts and morphology, testosterone levels, sexual behavior, and fertility parameters among experimental groups. Our results reinforce the idea that injuries provoked by experimental varicocele are related, at least in part, to oxidative stress. Moreover, varicocele showed bilateral deleterious effects without interfering with fertility. Chrysin administration significantly ameliorated sperm parameters, protecting the reproductive system against varicocele damages. For that reason, chrysin might be an alternative adjuvant therapy to improve sperm quality in men presenting this condition. (AU)

Processo FAPESP: 15/26309-3 - Desfechos reprodutivos da terapia antioxidante com crisina na varicocele experimental em ratos
Beneficiário:Gabriela Missassi
Linha de fomento: Bolsas no Brasil - Mestrado