Bacterial Chat: Intestinal Metabolites and Signals in Host-Microbiota-Pathogen Interactions

Autor(es)

Lustri, Bruna C. ^[1] ; Sperandio, Vanessa ^{[2, 3]} ; Moreira, Cristiano G. ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ, UNESP, Dept Biol Sci, Araraquara, SP - Brazil

^[2] Univ Texas Southwestern Med Ctr Dallas, Dept Microbiol, Dallas, TX 75390 - USA

^[3] Univ Texas Southwestern Med Ctr Dallas, Dept Biochem, Dallas, TX 75390 - USA

• Tipo de documento: Artigo de Revisão
• Fonte: Infection and Immunity; v. 85, n. 12 DEC 2017.
• Citações Web of Science: 22

Resumo

Intestinal bacteria employ microbial metabolites from the microbiota and chemical signaling during cell-to-cell communication to regulate several cellular functions. Pathogenic bacteria are extremely efficient in orchestrating their response to these signals through complex signaling transduction systems. Precise coordination and interpretation of these multiple chemical cues is important within the gastrointestinal (GI) tract. Enteric foodborne pathogens, such as enterohemorrhagic Escherichia coli (EHEC) and Salmonella enterica serovar Typhimurium, or the surrogate murine infection model for EHEC, Citrobacter rodentium, are all examples of microorganisms that modulate the expression of their virulence repertoire in response to signals from the microbiota or the host, such as autoinducer-3 (AI-3), epinephrine (Epi), and norepinephrine (NE). The QseBC and QseEF two-component systems, shared by these pathogens, are involved in sensing these signals. We review how these signaling systems sense and relay these signals to drive bacterial gene expression; specifically, to modulate virulence. We also review how bacteria chat via chemical signals integrated with metabolite recognition and utilization to promote successful associations among enteric pathogens, the microbiota, and the host. (AU)

• Processo FAPESP: 14/06779-2 - Investigação do papel da sinalização química e de mecanismos auxiliares na virulência de Salmonella enterica sorovar Typhimurium e outros enteropatógenos
• Beneficiário: Cristiano Gallina Moreira
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores