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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Serum markers as an aid in the diagnosis of pulmonary fungal infections in AIDS patients

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Autor(es):
Morsch Passos, Ana Isabela [1] ; Dertkigil, Rachel Polo [2] ; Ramos, Marcelo de Carvalho [1] ; Busso-Lopes, Ariane Fidelis [3] ; Tararan, Cibele [1] ; Ribeiro, Erivan Olinda [1] ; Schreiber, Angelica Zaninelli [4] ; Trabasso, Plinio [1] ; Resende, Mariangela Ribeiro [1] ; Moretti, Maria Luiza [1]
Número total de Autores: 10
Afiliação do(s) autor(es):
[1] Univ Estadual Campinas, Fac Ciencias Med, Dept Med Interna, Campinas, SP - Brazil
[2] Univ Estadual Campinas, Fac Ciencias Med, Dept Radiol, Campinas, SP - Brazil
[3] Lab Nacl Biociencias LNBio, Campinas, SP - Brazil
[4] Univ Estadual Campinas, Fac Ciencias Med, Dept Patol Clin, Campinas, SP - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: Brazilian Journal of Infectious Diseases; v. 21, n. 6, p. 606-612, NOV-DEC 2017.
Citações Web of Science: 1
Resumo

Introduction: The etiology of pulmonary infections in HIV patients is determined by several variables including geographic region and availability of antiretroviral therapy. Materials and methods: A cross-sectional prospective study was conducted from 2012 to 2016 to evaluate the occurrence of pulmonary fungal infection in HIV-patients hospitalized due to pulmonary infections. Patients' serums were tested for (1-3)-beta-D-Glugan, galactomannan, and lactate dehydrogenase. The association among the variables was analyzed by univariate and multivariate regression analysis. Results: 60 patients were included in the study. The patients were classified in three groups: Pneumocystis jirovecii pneumonia (19 patients), community-acquired pneumonia (18 patients), and other infections (23 patients). The overall mortality was 13.3%. The time since diagnosis of HIV infection was shorter in the pneumocystosis group (4.94 years; p = 0.001) than for the other two groups of patients. The multivariate analysis showed that higher (1-3)-beta-D-Glucan level (mean: 241 pg/mL) and lactate dehydrogenase (mean: 762 U/L) were associated with the diagnosis of pneumocystosis. Pneumocystosis was the aids-defining illness in 11 out of 16 newly diagnosed HIV-infected patients. Conclusion: In the era of antiretroviral therapy, PJP was still the most prevalent pulmonary infection and (1-3)-beta-D-Glucan and lactate dehydrogenase may be suitable markers to help diagnosing pneumocystosis in our HIV population. (C) 2017 Sociedade Brasileira de Infectologia. Published by Elsevier Editora Ltda. (AU)

Processo FAPESP: 12/51158-0 - Aplicação de novas tecnologias para o aprimoramento do diagnóstico e manejo das infeccções fúngicas em pacientes com AIDS e outras condições imunodepressoras
Beneficiário:Maria Luiza Moretti
Linha de fomento: Auxílio à Pesquisa - Regular