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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

The mongolian gerbil (Meriones unguiculatus) as a model for inflammation-promoted prostate carcinogenesis

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Autor(es):
Quintar, Amado A. [1] ; Goncalves, Bianca F. [2] ; Taboga, Sebastiao R. [2] ; Maldonado, Cristina A. [1]
Número total de Autores: 4
Afiliação do(s) autor(es):
[1] Univ Nacl Cordoba, Fac Ciencias Med, Inst Invest Ciencias Salud INICSA CONICET, Ctr Microscopia Elect, Cordoba - Argentina
[2] Univ Estadual Paulista UNESP, Inst Biociencias Letras & Ciencias Exatas IBILCE, Dept Biol, Sao Jose Do Rio Preto - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: Cell Biology International; v. 41, n. 11, SI, p. 1234-1238, NOV 2017.
Citações Web of Science: 1
Resumo

One of the recognized issues in prostate cancer research is the lack of animal models allowing the research of pathological, biochemical, and genetic factors in immunocompetent animals. Our research group has successfully employed the gerbil in several studies for prostate diseases. In the present work, we aimed to analyze the effect of chronic bacterial inflammation on N-methyl-N-nitrosourea (MNU)-induced prostate carcinogenesis in gerbils. Histopathological assessment of the prostatic complex revealed that treatment combinations with MNU plus testosterone or bacterial infection resulted in a promotion of prostate cancer, with bacterial inflammation being more effective in increasing premalignant and malignant tissular alterations than testosterone in the prostate. Furthermore, chronic bacterial inflammation itself induced premalignant lesions in the ventral lobe and increased their frequency in the dorsolateral lobe as well as malignant lesions in the ventral prostate. These animals showed a rich inflammatory microenvironment, characterized as intraluminal and periductal foci. These data indicate that chronic inflammation induced by Escherichia coli acts as a potent tumor promoter, in the early stages of carcinogenesis in the gerbil, in line with the hypothesis of inflammation supporting several steps of tumor development in the prostate gland. (AU)

Processo FAPESP: 14/26660-0 - Estudo do estroma reativo prostático após a orquiectomia bilateral e posterior inibição da atividade da aromatase pela crisina e inibição da atividade da 5-alfa-redutase pela finasterida
Beneficiário:Sebastião Roberto Taboga
Linha de fomento: Auxílio à Pesquisa - Regular