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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Vitamin C partially prevents reproductive damage in adult male rats exposed to rosuvastatin during prepuberty

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Autor(es):
Araujo Leite, Gabriel Adan [1, 2] ; Figueiredo, Thamiris Moreira [2] ; Pacheco, Taina Louise [2] ; Sanabria, Marciana [2] ; Villela e Silva, Patricia [2] ; Fernandes, Fabio Henrique [3] ; Kempinas, Wilma De Grava [2]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] State Univ Campinas UNICAMP, Inst Biol, Grad Program Cell & Struct Biol, Campinas, SP - Brazil
[2] Sao Paulo State Univ Unesp, Dept Morphol, Inst Biosci, Botucatu, SP - Brazil
[3] Sao Paulo State Univ Unesp, Grad Program Genet, Inst Biosci, Botucatu, SP - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: Food and Chemical Toxicology; v. 109, n. 1, p. 272-283, NOV 2017.
Citações Web of Science: 4
Resumo

Pediatric obesity is closely associated with dyslipidemias and environmental factors, such as diet and lack of physical exercises, which may alter lipid profile in children. Rosuvastatin decreases serum total cholesterol and triglycerides concentrations. Vitamin C (ascorbic acid) plays an important role on sperm integrity and fertility. Juvenile male rats were distributed into six experimental groups that received saline solution 0.9%, 3 or 10 mg/kg/day of rosuvastatin, 150 mg/day of ascorbic acid, or 3 or 10 mg/kg/day of rosuvastatin co-administered with 150 mg/day of ascorbic acid from PND23 until PND53 and then the rats were maintained until sexual maturity. Rosuvastatin-exposed groups showed lower sperm quality, androgen depletion and germ cell death. Ascorbic acid was capable to prevent partially the reproductive adverse effects provoked by rosuvastatin. In conclusion, prepubertal exposure to rosuvastatin provokes long-term reproductive damages at sexual maturity and ascorbic acid supplementation at prepuberty may be a preventive mode against these reproductive adverse effects. (C) 2017 Elsevier Ltd. All rights reserved. (AU)

Processo FAPESP: 14/13659-3 - Exposição de ratos machos à rosuvastatina na presença ou ausência de Vitamina C na pré-puberdade: efeitos imediatos e tardios sobre o sistema genital masculino
Beneficiário:Thamiris Moreira Figueiredo
Linha de fomento: Bolsas no Brasil - Iniciação Científica
Processo FAPESP: 13/22495-1 - Exposição de ratos machos à rosuvastatina na pré-puberdade, na ausência ou presença de vitamina C: efeitos imediatos e tardios sobre o sistema genital e a fertilidade das gerações F0 e F1
Beneficiário:Gabriel Adan Araújo Leite
Linha de fomento: Bolsas no Brasil - Doutorado