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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Genomic characterization and comparative analysis of Leptospira interrogans serogroup Australis isolated from swine

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Autor(es):
Moreno, Luisa Z. [1] ; Kremer, Frederico S. [2] ; Jaeger, Lauren H. [3] ; Loureiro, Ana P. [3] ; Miraglia, Fabiana [3] ; Eslabao, Marcos R. [2] ; Dellagostin, Odir A. [2] ; Lilenbaum, Walter [3] ; Moreno, Andrea M. [1]
Número total de Autores: 9
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Fac Med Vet & Zootecnia, Lab Epidemiol Mol & Resistencia Antimicrobianos, Av Prof Dr Orlando Marques de Paiva 87, BR-05508270 Sao Paulo, SP - Brazil
[2] Univ Fed Pelotas, Nucleo Biotecnol, Ctr Desenvolvimento Tecnol, BR-96160000 Pelotas, RS - Brazil
[3] Univ Fed Fluminense, Dept Microbiol & Parasitol, Lab Bacteriol Vet, Hernani Mello 101, BR-24210130 Niteroi, RJ - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: PATHOGENS AND DISEASE; v. 75, n. 9 DEC 2017.
Citações Web of Science: 0
Resumo

The Leptospira interrogans serogroup Australis is traditionally described as pathogenic for swine although animals usually present low serologic response and mild clinical signs. The first isolation of a Leptospira interrogans serogroup Australis strain from swine, in Brazil, was recently described. Herein we present the genomic characterization of this strain (SU5) and further comparison with the Leptospira serovars reference genomes available in the GenBank database. The SU5 strain was characterized with sequence types previously described in a serogroup Australis isolated from human and presented a new ST98 that is thus far exclusively of the Brazilian porcine L. interrogans serogroup Australis. Even though the SU5 strain presented higher similarity with the American porcine serogroup Australis strain PigK151, as expected, it also presented sequences blocks in both chromosomes which are absent in the genomes of the studied Leptospira serovars. These regions are flanked by insertion sequences and transposases genes, suggesting the existence of inter-and intra-serogroup genomic variability due to mobile elements transferring. This genomic plasticity has already been demonstrated for pathogenic Leptospira species; nevertheless, there is still a limited understanding of the relationship between genome organization and content and the divergence of Leptospira serogroups and serovars that needs to be further elucidated. (AU)

Processo FAPESP: 13/17136-2 - Caracterização de estirpes de Leptospira isoladas no Brasil através de tipificação por eletroforese em campo pulsado (PFGE) e análise comparativa de genomas
Beneficiário:Luisa Zanolli Moreno
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 11/18290-0 - Caracterização de estirpes de Leptospira isoladas no Brasil através da tipagem por sequenciamento de multilocus (MLST)
Beneficiário:Andrea Micke Moreno
Linha de fomento: Auxílio à Pesquisa - Regular