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Correlation of Beta-2 Adrenergic Receptor Expression in Tumor-Free Surgical Margin and at the Invasive Front of Oral Squamous Cell Carcinoma

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Autor(es):
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Oliveira, Denise Tostes [1] ; Bravo-Calderon, Diego Mauricio [1] ; Lauand, Gustavo Amaral [1] ; Assao, Agnes [1] ; Suarez-Penaranda, Jose-Manuel [2, 3] ; Perez-Sayans, Mario [4] ; Garcia-Garcia, Abel [4] ; Marana, Aparecido Nilceu [5] ; Nonogaki, Suely [6] ; Pereira Lauris, Jose Roberto [7] ; Kowalski, Luiz Paulo [8]
Número total de Autores: 11
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Bauru Sch Dent, Dept Stomatol, Area Pathol, BR-17012901 Bauru, SP - Brazil
[2] Univ Hosp, Dept Pathol & Forens Sci, Santiago De Compostela 15706, Galicia - Spain
[3] Sch Med Santiago de Compostela, Santiago De Compostela 15706, Galicia - Spain
[4] Clin Hosp Univ Santiago, Inst Res Santiago de Compostela IDIS, Fac Med & Dent, Santiago De Compostela 15782, A Coruna - Spain
[5] Sao Paulo State Univ UNESP, Fac Sci, Dept Comp, BR-17033360 Bauru, SP - Brazil
[6] Adolfo Lutz Inst, Div Pathol, BR-01246902 Sao Paulo, SP - Brazil
[7] Univ Sao Paulo, Bauru Sch Dent, Dept Community Dent, BR-17012901 Bauru, SP - Brazil
[8] AC Camargo Canc Ctr, Dept Head & Neck Surg & Otorhinolaryngol, BR-01509010 Sao Paulo, SP - Brazil
Número total de Afiliações: 8
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF ONCOLOGY; 2016.
Citações Web of Science: 0
Resumo

Background. The beta-2 adrenergic receptor is expressed by neoplastic cells and is correlated with a wide spectrum of tumor cell mechanisms including proliferation, apoptosis, angiogenesis, migration, and metastasis. Objectives. The present study aimed to analyze the expression of the beta-2 adrenergic receptor (beta 2-AR) in tumor-free surgical margins of oral squamous cell carcinomas (OSCC) and at the invasive front. Sixty-two patients diagnosed with OSCC, confirmed by biopsy, were selected for the study. The clinicopathological data and clinical follow-up were obtained from medical records and their association with beta 2-AR expression was verified by the chi-square test or Fischer's exact test. To verify the correlation of beta 2-AR expression in tumor-free surgical margins and at the invasive front of OSCCs, Pearson's correlation coefficient test was applied. Results. The expression of beta 2-AR presented a statistically significant correlation between the tumor-free surgical margins and the invasive front of OSCC (p = 0.383; p = 0.002). The immunohistochemical distribution of beta 2-AR at the invasive front of OSCC was also statistically significant associated with alcohol (p = 0.038), simultaneous alcohol and tobacco consumption (p = 0.010), and T stage (p = 0.014). Conclusions. The correlation of beta 2-AR expression in OSCC and tumor-free surgical margins suggests a role of this receptor in tumor progression and its expression in normal oral epithelium seems to be constitutive. (AU)

Processo FAPESP: 12/04098-2 - Expressão do receptor beta-2 adrenérgico nos tecidos a fresco de carcinomas espinocelulares de boca
Beneficiário:Gustavo Amaral Lauand
Linha de fomento: Bolsas no Exterior - Estágio de Pesquisa - Iniciação Científica
Processo FAPESP: 11/11630-0 - Comparação do receptor beta-2-adrenérgico na mucosa bucal de margens cirúrgicas e nas células malignas do carcinoma espinocelular de boca
Beneficiário:Gustavo Amaral Lauand
Linha de fomento: Bolsas no Brasil - Iniciação Científica