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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Fishing Into the MicroRNA Transcriptome

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Autor(es):
Herkenhoff, Marcos E. [1] ; Oliveira, Arthur C. [1] ; Nachtigall, Pedro G. [1] ; Costa, Juliana M. [1] ; Campos, Vinicius F. [2] ; Hilsdorf, Alexandre W. S. [3] ; Pinhal, Danillo [1]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Sao Paulo State Univ, Inst Biosci Botucatu, Dept Genet, Lab Genom & Mol Evolut, Botucatu, SP - Brazil
[2] Univ Fed Pelotas, Technol Dev Ctr, Lab Struct Genom GenEstrut, Grad Program Biotechnol, Pelotas - Brazil
[3] Univ Mogi das Cruzes, Unit Biotechnol, Mogi Das Cruzes - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo de Revisão
Fonte: FRONTIERS IN GENETICS; v. 9, MAR 19 2018.
Citações Web of Science: 6
Resumo

In the last decade, several studies have been focused on revealing the microRNA (miRNA) repertoire and determining their functions in farm animals such as poultry, pigs, cattle, and fish. These small non-protein coding RNA molecules (18-25 nucleotides) are capable of controlling gene expression by binding to messenger RNA (mRNA) targets, thus interfering in the final protein output. MiRNAs have been recognized as the main regulators of biological features of economic interest, including body growth, muscle development, fat deposition, and immunology, among other highly valuable traits, in aquatic livestock. Currently, the miRNA repertoire of some farmed fish species has been identified and characterized, bringing insights about miRNA functions and novel perspectives for improving health and productivity. In this review, we summarize the current advances in miRNA research by examining available data on Neotropical and other key species exploited by fisheries and in aquaculture worldwide and discuss how future studies on Neotropical fish could benefit from this knowledge. We also make a horizontal comparison of major results and discuss forefront strategies for miRNA manipulation in aquaculture focusing on forward-looking ideas for forthcoming research. (AU)

Processo FAPESP: 14/03062-0 - Caracterização molecular de híbridos heteróticos das linhagens Red Stirling e Chitralada da Tilápia do Nilo (Oreochromis niloticus)
Beneficiário:Marcos Edgar Herkenhoff
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 12/15589-7 - Investigação da composição, funcionalidade e dinâmica evolutiva de microRNAs no genoma de peixes utilizando RNA-Seq e genética reversa
Beneficiário:Danillo Pinhal
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 13/06864-7 - Análise funcional de microRNAs no desenvolvimento cardíaco de peixes por RNA-seq e genética reversa
Beneficiário:Pedro Gabriel Nachtigall
Linha de fomento: Bolsas no Brasil - Doutorado