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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Detection and genotyping of human papillomavirus (HPV) in HIV-infected women and its relationship with HPV/HIV co-infection

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Autor(es):
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Badial, Rodolfo Miglioli [1] ; Dias, Marina Carrara [1] ; Stuqui, Bruna [1] ; dos Santos Melli, Patricia Pereira [2] ; Quintana, Silvana Maria [3] ; do Bonfim, Caroline Measso [1] ; Cordeiro, Jose Antonio [4] ; Rabachini, Tatiana [5] ; Calmon, Marilia de Freitas [1] ; Scarin Provazzi, Paola Jocelan [1] ; Rahal, Paula [1]
Número total de Autores: 11
Afiliação do(s) autor(es):
[1] Sao Paulo State Univ UNESP, Dept Biol, Sao Jose Do Rio Preto, SP - Brazil
[2] Hosp Ribeirao Preto, Sch Med HC FMRP, Dept Obstet & Gynecol, Sao Jose Do Rio Preto, SP - Brazil
[3] Univ Sao Paulo, Med Sch Ribeirao Preto, Dept Gynecol & Obstet, Sao Jose Do Rio Preto, SP - Brazil
[4] Fac Med Sao Jose do Rio Preto FAMERP, Dept Epidemiol & Publ Hlth, Sao Jose Do Rio Preto, SP - Brazil
[5] Univ Bern, Inst Pharmacol, Bern - Switzerland
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: MEDICINE; v. 97, n. 14 APR 2018.
Citações Web of Science: 3
Resumo

HPV have been identified as high-risk and low-risk, depending on their association with the development of cancer. HPV infections can be facilitated by co-infection with HIV. Here, we investigated HPV prevalence and genotypes and the risk factors affecting HPV/HIV co-infection. Forty HIV-positive patients had 80 cervical swab samples collected in 2 consecutive years. Polymerase chain reaction and DNA direct sequencing were used to perform HPV genotyping. Statistical analyses were performed regarding risk factors for HPV/HIV co-infection and the occurrence of cervical lesions. HPV DNA was detected in 59 samples (73.75%), and high-risk HPVs were predominant (59.3%). The most prevalent type was HPV56 (17%), followed by HPV16 (15.3%). Patient age did not affect the risk of cervical cancer (P=.84) or HPV prevalence in different years (P=.25/P=.63). CD4 count also did not affect the risk for cervical lesions in the tested samples (P=.15/P=.28). Although the HIV viral load was not correlated with an increase in cervical lesion detection in the first group of analyzed samples (P=.12), it did affect cervical cancer risk in the group of samples analyzed in the following year (P=.045). HIV-infected patients presented a high prevalence of HPV co-infection, and HPV16 and HPV56 were the most prevalent genotypes. Considering this, it is possible that immunodeficiency can contribute to increased susceptibility to HPV56 infection in HIV-infected patients. The association between HIV viral load and the lesions also confirmed the importance of monitoring HIV/HPV co-infected patients with high HIV viral loads. (AU)

Processo FAPESP: 14/02064-9 - Análise da ação antiviral do composto natural curcumina associado a nanopartículas em linhagens celulares de carcinoma de vulva HPV-16 positivas e negativas
Beneficiário:Caroline Measso Do Bonfim
Linha de fomento: Bolsas no Brasil - Pós-Doutorado