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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Default Mode Network Disruption in Stroke-Free Patients with Atrial Fibrillation

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Autor(es):
Silva, Danilo S. [1, 2] ; Avelar, Wagner M. [1, 2] ; de Campos, Brunno M. [3, 1] ; Lino, Ana Paula B. L. [4] ; Balthazar, Marcio L. F. [3, 1] ; Figueiredo, Marcio J. O. [4] ; Cendes, Fernando [3, 1] ; Coan, Ana Carolina [3, 1]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Univ Estadual Campinas, Brazilian Inst Neurosci & Neurotechnol, BRAINN, Campinas, SP - Brazil
[2] Univ Estadual Campinas, Dept Neurol, Neurovasc Grp, UNICAMP, Campinas, SP - Brazil
[3] Univ Estadual Campinas, Dept Neurol, UNICAMP, Neuroimaging Lab, Campinas, SP - Brazil
[4] Univ Estadual Campinas, Dept Cardiol, UNICAMP, Campinas, SP - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: CEREBROVASCULAR DISEASES; v. 45, n. 1-2, p. 78-84, 2018.
Citações Web of Science: 1
Resumo

Background: Atrial fibrillation (AF) is a widely accepted risk for causing stroke. However, recent studies show AF as a risk factor for dementia, even without causing stroke. The mechanisms by which dementia develops in stroke-free patients with AF are still poorly understood and the association of AF with abnormal function of brain networks activities, such as the default mode network (DMN), has not been previously studied. We aimed to determine whether, in the absence of stroke and dementia, patients with AF have abnormal resting-state brain networks compared to controls without AF. Methods: Twenty-one stroke-free patients with AF and 21 age-and sex-matched controls without AF underwent brain functional magnetic resonance imaging acquired at a 3.0 Tesla scanner. During the exam, the subjects were instructed to lie still with eyes closed. At first-level analysis, connectivity of the DMN was obtained for all subjects. Second-level analysis compared the DMN connectivity between AF patients and controls with a general linear model (two-sample t test, p < 0.05, False Discovery Rate corrected, minimum of 50 contiguous voxels). Results: Patients with AF compared with controls showed decreased connectivity in regions of the DMN including the frontal lobe (left medial frontal gyrus, left superior frontal gyrus and anterior cingulate), left angular gyrus, and bilateral precuneus. Conclusions: Stroke-free patients with AF have evidence of abnormal DMN connectivity. This study adds evidence to the occurrence of cerebral dysfunction in patients with AF. (c) 2018 S. Karger AG, Basel (AU)

Processo FAPESP: 13/07559-3 - Instituto Brasileiro de Neurociência e Neurotecnologia - BRAINN
Beneficiário:Fernando Cendes
Linha de fomento: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
Processo FAPESP: 13/00099-7 - Aprimoramento da técnica de EEG-RMf na avaliação pré-operatória de pacientes com epilepsias focais refratárias
Beneficiário:Ana Carolina Coan
Linha de fomento: Bolsas no Brasil - Pós-Doutorado