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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Role of Beta-adrenergic Receptors and Sirtuin Signaling in the Heart During Aging, Heart Failure, and Adaptation to Stress

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Autor(es):
Spadari, Regina Celia [1, 2] ; Cavadas, Claudia [3, 4] ; Saturi de Carvalho, Ana Elisa T. [1] ; Ortolani, Daniela [1, 5] ; de Moura, Andre Luiz [1] ; Vassalo, Paula Frizera [5, 6]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo UNIFESP, Lab Stress Biol, Dept Biosci, Campus Baixada Santista, Santos - Brazil
[2] UNIFESP, Dept Biociencias, Campus Baixada Santista, Rua Silva Jardim 136, BR-11015020 Santos, SP - Brazil
[3] Univ Coimbra, Ctr Neurosci & Cell Biol CNC, Coimbra - Portugal
[4] Univ Coimbra, Sch Pharm, Coimbra - Portugal
[5] Univ Fed Espirito Santo, Dept Physiol Sci, HUCAM, Vitoria - Brazil
[6] Univ Fed Espirito Santo, Univ Hosp Cassiano Antonio de Moraes, HUCAM, Vitoria - Brazil
Número total de Afiliações: 6
Tipo de documento: Artigo de Revisão
Fonte: Cellular and Molecular Neurobiology; v. 38, n. 1, SI, p. 109-120, JAN 2018.
Citações Web of Science: 9
Resumo

In the heart, catecholamine effects occur by activation of beta-adrenergic receptors (beta-ARs), mainly the beta 1 (beta(1)-AR) and beta 2 (beta(2)-AR) subtypes, both of which couple to the Gs protein that activates the adenylyl cyclase signaling pathway. The beta(2)-ARs can also couple to the Gi protein that counterbalances the effect of the Gs protein on cyclic adenosine monophosphate production and activates the phosphatidylinositol 3-kinase (PI3K)-Akt signaling pathway. In several cardiovascular disorders, including heart failure, as well as in aging and in animal models of environmental stress, a reduction in the beta(1)/beta(2)-AR ratio and activation of the beta(2)-AR-Gi-PI3K-Akt signaling pathway have been observed. Recent studies have shown that sirtuins modulate certain organic processes, including the cellular stress response, through activation of the PI3K-Akt signaling pathway and of downstream molecules such as p53, Akt, HIF1-alpha, and nuclear factor-kappa B. In the heart, SIRT1, SIRT3, and beta(2)-ARs are crucial to the regulation of the cardiomyocyte energy metabolism, oxidative stress, reactive oxygen species production, and autophagy. SIRT1 and the beta(2)-AR-Gi complex also control signaling pathways of cell survival and death. Here, we review the role played by beta(2)-ARs and sirtuins during aging, heart failure, and adaptation to stress, focusing on the putative interplay between the two. That relationship, if proven, merits further investigation in the context of cardiac function and dysfunction. (AU)

Processo FAPESP: 12/21990-6 - Papel das óxido nítrico sintases e adrenoceptores beta no tecido cardíaco de ratos submetidos a estresse com acesso a Comfort food
Beneficiário:Regina Celia Spadari
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 16/20777-8 - O papel das sirtuínas sobre a sinalização beta 2 adrenérgica em coração de ratos submetidos ao estresse
Beneficiário:Regina Celia Spadari
Linha de fomento: Auxílio à Pesquisa - Regular