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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Structure/Activity of Pt-II/& IT;N & IT;,& IT;N & IT;-Disubstituted-& IT;N & IT;'-acylthiourea Complexes: Anti-Tumor and Anti-& IT;Mycobacterium tuberculosis & IT; Activities

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Autor(es):
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Plutin, Ana M. [1] ; Alvarez, Anislay [1] ; Mocelo, Raul [1] ; Ramos, Raul [1] ; Sanchez, Osmar C. [1] ; Castellano, Eduardo E. [2] ; da Silva, Monize M. [3] ; Villarreal, Wilmer [3] ; Colina-Vegas, Legna [3] ; Pavan, Fernando R. [4] ; Batista, Alzir A. [3]
Número total de Autores: 11
Afiliação do(s) autor(es):
[1] Univ La Habana, Fac Quim, Lab Sintesis Organ, Havana 10400 - Cuba
[2] Univ Sao Paulo, Inst Fis Sao Carlos, BR-05508090 Sao Carlos, SP - Brazil
[3] Univ Fed Sao Carlos, Dept Quim, BR-13565905 Sao Carlos, SP - Brazil
[4] Univ Estadual Paulista UNESP, Fac Ciencias Farmaceut, BR-14800903 Araraquara, SP - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: Journal of the Brazilian Chemical Society; v. 29, n. 6, p. 1256-1267, JUN 2018.
Citações Web of Science: 1
Resumo

The syntheses, characterization, cytotoxicity against tumor cells and anti-Mycobacterium tuberculosis activity assays of Pt-II/PPh3/N,N-disubstituted-N'-acylthioureas complexes with general formulae {[}Pt(PPh3)(2)(L)]PF6, PPh3 = triphenylphosphine; L = N,N-disubstituted-N'-acylthiourea, are here reported. The complexes were characterized by elemental analysis, molar conductivity, infrared (IR), nuclear magnetic resonance (NMR) (H-1, C-13[H-1] and P-31[H-1]) spectroscopy. The P-31[H-1] NMR data are consistent with the presence of two PPh 3 ligands cis to each other position, and one N,N-disubstituted-N'-acylthiourea coordinated to the metal through O and S, in a chelate form. The structures of the complexes were determined by X-ray crystallography, forming distorted square-planar structures. The complexes were tested in human cell lines carcinomas and also screened with respect to their anti-Mycobacterium tuberculosis activity (H37RvATCC 27294). It was found that complexes with N,N-disubstituted-N'-acylthiourea containing open and small chains as R2 groups show higher cytotoxic and higher anti-Mycobacterium tuberculosis activity than those containing rings in this position. (AU)

Processo FAPESP: 14/10516-7 - Busca por complexos de rutênio (II), com propriedades quimioterapêuticas: avaliação de possíveis efeitos sinergísticos e possíveis mecanismo de ação
Beneficiário:Alzir Azevedo Batista
Linha de fomento: Auxílio à Pesquisa - Regular