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(Referência obtida automaticamente do SciELO, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Structure/Activity of PtII/N,N-Disubstituted-N'-acylthiourea Complexes: Anti-Tumor and Anti-Mycobacterium tuberculosis Activities

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Ana M. Plutín ; Anislay Alvarez ; Raúl Mocelo ; Raúl Ramos ; Osmar C. Sánchez ; Eduardo E. Castellano ; Monize M. da Silva ; Wilmer Villarreal ; Legna Colina-Vegas ; Fernando R. Pavan ; Alzir A. Batista
Número total de Autores: 11
Tipo de documento: Artigo Científico
Fonte: Journal of the Brazilian Chemical Society; v. 29, n. 6, p. -, Jun. 2018.
Resumo

The syntheses, characterization, cytotoxicity against tumor cells and anti-Mycobacterium tuberculosis activity assays of PtII/PPh3/N,N-disubstituted-N'-acylthioureas complexes with general formulae [Pt(PPh3)2(L)]PF6, PPh3 = triphenylphosphine; L = N,N-disubstituted-N'-acylthiourea, are here reported. The complexes were characterized by elemental analysis, molar conductivity, infrared (IR), nuclear magnetic resonance (NMR) (1H, 13C{1H} and 31P{1H}) spectroscopy. The 31P{1H} NMR data are consistent with the presence of two PPh3 ligands cis to each other position, and one N,N-disubstituted-N'-acylthiourea coordinated to the metal through O and S, in a chelate form. The structures of the complexes were determined by X-ray crystallography, forming distorted square-planar structures. The complexes were tested in human cell lines carcinomas and also screened with respect to their anti-Mycobacterium tuberculosis activity (H37RvATCC 27294). It was found that complexes with N,N-disubstituted-N'-acylthiourea containing open and small chains as R2 groups show higher cytotoxic and higher anti-Mycobacterium tuberculosis activity than those containing rings in this position. (AU)

Processo FAPESP: 14/10516-7 - Busca por complexos de rutênio (II), com propriedades quimioterapêuticas: avaliação de possíveis efeitos sinergísticos e possíveis mecanismo de ação
Beneficiário:Alzir Azevedo Batista
Linha de fomento: Auxílio à Pesquisa - Regular