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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Mesenchymal stromal cells modulate gut inflammation in experimental colitis

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Autor(es):
de Aguiar, Cristhiane Favero [1] ; Castoldi, Angela [1] ; Andrade-Oliveira, Vinicius [1] ; Ignacio, Aline [1] ; da Cunha, Flavia Franco [2] ; Ferreira Felizardo, Raphael Jose [2] ; Bassi, Enio Jose [3] ; Saraiva Camara, Niels Olsen [2, 1, 4, 5] ; de Almeida, Danilo Candido [2, 1, 4]
Número total de Autores: 9
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Inst Biomed Sci 4, Dept Immunol, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Nephrol Div, Dept Med, Sao Paulo - Brazil
[3] Univ Fed Alagoas, Inst Biol Sci & Hlth, Alagoas - Brazil
[4] Av Prof Lineu Prestes 1730 Lab 238 Cidade Univ, BR-05508000 Sao Paulo, SP - Brazil
[5] Univ Sao Paulo, Sch Med, LIM 16, Sao Paulo - Brazil
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: INFLAMMOPHARMACOLOGY; v. 26, n. 1, p. 251-260, FEB 2018.
Citações Web of Science: 3
Resumo

Inflammatory bowel diseases (IBDs) affect millions of people worldwide and their frequencies in developed countries have increased since the twentieth century. In this context, there is an intensive search for therapies that modulate inflammation and provide tissue regeneration in IBDs. Recently, the immunomodulatory activity of adipose tissue-derived mesenchymal stromal cells (ADMSCs) has been demonstrated to play an important role on several immune cells in different conditions of inflammatory and autoimmune diseases. In this study, we explored the immunomodulatory potential of ADMSC in a classical model of DSS-induced colitis. First, we found that treatment of mice with ADMSC ameliorated the severity of DSS-induced colitis, reducing colitis pathological score and preventing colon shortening. Moreover, a prominent reduction of pro-inflammatory cytokines levels (i.e., IFN-gamma, TNF-alpha, IL-6 and MCP-1) was observed in the colon of animals treated with ADMSC. We also observed a significant reduction in the frequencies of macrophages (F4/80(+)CD11b(+)) and dendritic cells (CD11c(+)CD103(+)) in the intestinal lamina propria of ADMSC-treated mice. Finally, we detected the up-regulation of immunoregulatory-associated molecules in intestine of mice treated with ADMSCs (i.e., elevated arginase-1 and IL-10). Thus, this present study demonstrated that ADMSC modulates the overall gut inflammation (cell activation and recruitment) in experimental colitis, providing support to the further development of new strategies in the treatment of intestinal diseases. (AU)

Processo FAPESP: 12/16794-3 - Influência da microbiota intestinal na participação e no perfil das células NKT num modelo experimental de colite
Beneficiário:Cristhiane Favero de Aguiar
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 12/02270-2 - Novos mecanismos celulares, moleculares e imunológicos das lesões renais agudas e crônicas: busca por novas estratégias terapêuticas
Beneficiário:Niels Olsen Saraiva Câmara
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 13/25327-2 - O papel do microambiente inflamatório na ativação e biologia das células-troncos mesenquimais
Beneficiário:Danilo Candido de Almeida
Linha de fomento: Bolsas no Brasil - Pós-Doutorado