Glucagon-Like Peptides 1 and 2 Are Involved in Satiety Modulation After Modified Biliopancreatic Diversion: Results of a Pilot Study

Autor(es)

Cazzo, Everton ^[1] ; Pareja, Jose Carlos ^[1] ; Chaim, Elinton Adami ^[1] ; Rodrigues Coy, Claudio Saddy ^[1] ; Magro, Daniela Oliveira ^[1]

Afiliação do(s) autor(es)

^[1] State Univ Campinas UNICAMP, Fac Med Sci, Dept Surg, R Alexander Fleming S-N, Cidade Univ Zeferino Vaz, BR-13085000 Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: OBESITY SURGERY; v. 28, n. 2, p. 506-512, FEB 2018.
• Citações Web of Science: 1

Resumo

Background This paper aimed to evaluate the influence of modified biliopancreatic diversion (BPD) on the levels of GLP-1 and GLP-2 and correlate them with satiety regulation. Methods This is a pilot prospective cohort study that evaluated six mildly obese individuals with type 2 diabetes mellitus, which underwent modified BPD and were followed-up for 12 months. Levels of GLP-1 and GLP-2 after a standard meal tolerance test were determined and correlated with satiety scores obtained by means of a visual analogue scale (VAS). Results There were significant changes in BMI (33 +/- 2.2 versus 26.3 +/- 2.2 kg/m(2); p < 0.001), HbA1c (7.9 +/- 1.6 versus 5.8 +/- 1.2%; p = 0.026), total cholesterol (172.3 +/- 11.1 versus 134.7 +/- 16.1 mg/dL; p < 0.001), LDL-c (103.3 +/- 13 versus 64.6 +/- 12.2 mg/dL; p < 0.001), and postprandial GLP-2 (972.7 +/- 326.2 versus 1993.2 +/- 1024.7; p = 0. 044). None of the scores obtained in the VAS significantly changed after surgery. After surgery, there were significant correlations of VAS scores and GLP-1 levels in question 01 ({''}how hungry do you feel?{''}; R = -0.928; p = .008) and GLP-2 levels in questions 02 ({''}how full do you feel?{''} R = 0.943; p = 0.005) and 04 ({''}how much do you think you can eat now? R = -0.829; p = 0.042). Conclusions Modified BPD does not lead to significant changes in satiety evaluated by the VAS; different aspects of satiety regulation are correlated with the postprandial levels of GLP-1 (hunger feeling) and GLP-2 (satiation feeling and desire to eat) 1 year after modified BPD, signaling a specific postoperative gut hormone-related modulation of appetite. (AU)

• Processo FAPESP: 09/50430-6 - Modulacao dos hormonios gastrointestinais em pacientes submetidos as cirurgias bariatrica e metabolica e sua influencia sobre a tolerancia alimentar.
• Beneficiário: Daniéla Oliveira Magro
• Modalidade de apoio: Auxílio à Pesquisa - Regular