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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

The increasing burden of cancer attributable to high body mass index in Brazil

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Autor(es):
Machado de Rezende, Leandro Fornias [1] ; Arnold, Melina [2] ; Rabacow, Fabiana Maluf [3, 4] ; Levy, Renata Bertazzi [1] ; Claro, Rafael Moreira [5] ; Giovannucci, Edward [6, 7, 8, 9] ; Eluf-Neto, Jose [1]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Fac Med, Dept Med Prevent, Sao Paulo, SP - Brazil
[2] Int Agcy Res Canc, Sect Canc Surveillance, Lyon - France
[3] Univ Catolica Dom Bosco, Campo Grande - Brazil
[4] Univ Anhanguera Uniderp, Campo Grande - Brazil
[5] Univ Fed Minas Gerais, Dept Nutr, Belo Horizonte, MG - Brazil
[6] Harvard Med Sch, Boston, MA - USA
[7] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA - USA
[8] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA - USA
[9] Brigham & Womens Hosp, Channing Div Network Med, 75 Francis St, Boston, MA 02115 - USA
Número total de Afiliações: 9
Tipo de documento: Artigo Científico
Fonte: CANCER EPIDEMIOLOGY; v. 54, p. 63-70, JUN 2018.
Citações Web of Science: 6
Resumo

Background: Body mass index (BMI) has been constantly increasing over the last decades in most parts of the world, most notably in transitioning nations such as Brazil. High BMI ( > 22 kg/m(2)) is associated with an in-creased risk of 14 types of cancer. We estimated the extent to which reducing high BMI could lower cancer incidence in Brazil, nationally as well as M regional and state levels. Methods: We calculated fractions of cancer incidence in 2012 attributable to high BMI as well as projections for attributable cases in 2025 using BMI data from representative national surveys and relative risks published in meta-analyses. Estimates of cancer incidence were retrieved from GLOBOCAN and the Brazilian National Cancer Institute. Results: We found that 15,465 (3.8%) of all new cancer cases diagnosed in Brazil in 2012 were attributable to high BMI, with a higher burden in women (5.2%) than in men (2.6%). The cancer sites contributing most to the number of attributable cases were breast (n = 4777), corpus uteri (n = 1729), and colon (n = 681) in women, and colon (n = 1062), prostate (n = 926), and liver (n = 651) in men. The highest population attributable fractions (PAFs) for all cancers were found in the richer states of the country, located in the south (1.5% men/ 3.4% women) and the southeast (1.5% men/3.3% women). Conclusions: Cancer cases attributable to high BMI will reach 29,490, which will be 4.6% of all cancers in Brazil in 2025; the extent will be greater in women (6.2% or 18,837) than in men (3.2% or 10,653). This information is a tool to support policy makers for future cancer prevention strategies in Brazil. (AU)

Processo FAPESP: 16/21390-0 - Carga do câncer atribuível ao estilo de vida no Brasil
Beneficiário:Leandro Fórnias Machado de Rezende
Linha de fomento: Bolsas no Exterior - Estágio de Pesquisa - Doutorado
Processo FAPESP: 14/25614-4 - Inatividade física e câncer: da avaliação da evidência etiológica ao impacto na saúde pública
Beneficiário:Leandro Fórnias Machado de Rezende
Linha de fomento: Bolsas no Brasil - Doutorado