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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Fructooligosaccharide intake promotes epigenetic changes in the intestinal mucosa in growing and ageing rats

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Autor(es):
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Lima, Glaucia Carielo [1] ; Correa Vieira, Vivian Cristine [1] ; Betim Cazarin, Cinthia Bau [1] ; Ribeiro, Rafaela da Rosa [2] ; Bogusz Junior, Stanislau [3] ; de Albuquerque, Cibele Lima [2] ; Vidal, Ramon Oliveira [4] ; Netto, Claudia Cardoso [5] ; Yamada, Aureo Tatsumi [2] ; Augusto, Fabio [6] ; Marostica Junior, Mario Roberto [1, 7]
Número total de Autores: 11
Afiliação do(s) autor(es):
[1] Univ Estadual Campinas, Sch Food Engn, Campinas, SP - Brazil
[2] Univ Estadual Campinas, Inst Biol, Campinas, SP - Brazil
[3] Univ Sao Paulo, Inst Chem, Sao Carlos, SP - Brazil
[4] Univ Montreal, St Justine Univ Hosp Ctr, Montreal, PQ - Canada
[5] Univ Fed Rio de Janeiro, Dept Biochem, Biol Sci & Hlth Ctr, Rio De Janeiro - Brazil
[6] Univ Estadual Campinas, Inst Chem, Campinas, SP - Brazil
[7] Univ Estadual Campinas, Fac Engn Alimentos, Dept Alimentos Nutr, Lab Nutr & Metab, R Monteiro Lobato 80, BR-13083862 Campinas, SP - Brazil
Número total de Afiliações: 7
Tipo de documento: Artigo Científico
Fonte: EUROPEAN JOURNAL OF NUTRITION; v. 57, n. 4, p. 1499-1510, JUN 2018.
Citações Web of Science: 1
Resumo

Purpose The aim of this study was to investigate the relationship between fructooligosaccharide (FOS) intake at different life stages of Wistar rats and its stimulatory effects on intestinal parameters. Methods Recently weaned and ageing female rats were divided into growing and ageing treatments, which were fed diets that partially replaced sucrose with FOS for 12 weeks. Results Dietary FOS intake induced a significant increase in the numbers of Bifidobacterium and Lactobacillus in growing rats. FOS intake was associated with increased butyric acid levels and a reduced pH of the caecal contents at both ages. Differential gene expression patterns were observed by microarray analysis of growing and ageing animals fed the FOS diet. A total of 133 genes showed detectable changes in expression in the growing rats, while there were only 19 gene expression changes in ageing rats fed with FOS. Conclusion These results suggest that dietary FOS intake may be beneficial for some parameters of intestinal health in growing rats. (AU)

Processo FAPESP: 10/16752-3 - Avaliação do consumo da casca de Passiflora edulis e seu impacto na inflamação intestinal de ratos com colite ulcerativa
Beneficiário:Cinthia Baú Betim Cazarin
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 10/05681-8 - Efeito dos oligossacarídeos não digeríveis FOS e GOS no intestino e metabolismo ósseo de ratas Wistar em diferentes períodos da vida
Beneficiário:Mário Roberto Maróstica Junior
Linha de fomento: Auxílio à Pesquisa - Regular