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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

The role of mitochondria in the female germline: Implications to fertility and inheritance of mitochondrial diseases

Texto completo
Autor(es):
Chiaratti, Marcos Roberto [1, 2] ; Garcia, Bruna Martins [1] ; Carvalho, Karen Freire [1] ; Machado, Thiago Simoes [1, 2] ; da Silva Ribeiro, Fernanda Karina [1] ; Macabelli, Carolina Habermann [1]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Univ Fed Sao Carlos, Dept Genet & Evolucao, BR-13565905 Sao Carlos, SP - Brazil
[2] Univ Sao Paulo, Fac Med Vet & Zootecnia, BR-05508270 Sao Paulo, SP - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo de Revisão
Fonte: Cell Biology International; v. 42, n. 6, SI, p. 711-724, JUN 2018.
Citações Web of Science: 4
Resumo

Mitochondria play a fundamental role during development of the female germline. They are fragmented, round, and small. Despite these characteristics suggesting that they are inactive, there is accumulating evidence that mitochondrial dysfunctions are a major cause of infertility and generation of aneuploidies in humans. In addition, mitochondria and their own genomes (mitochondrial DNAmtDNA) may become damaged with time, which might be one reason why aging leads to infertility. As a result, mitochondria have been proposed as an important target for evaluating oocyte and embryo quality, and developing treatments for female infertility. On the other hand, mutations in mtDNA may cause mitochondrial dysfunctions, leading to severe diseases that affect 1 in 4,300 people. Moreover, very low levels of mutated mtDNA seem to be present in every person worldwide. These may increase with time and associate with late-onset degenerative diseases such as Parkinson disease, Alzheimer disease, and common cancers. Mutations in mtDNA are transmitted down the maternal lineage, following a poorly understood pattern of inheritance. Recent findings have indicated existence in the female germline of a purifying filter against deleterious mtDNA variants. Although the underlying mechanism of this filter is largely unknown, it has been suggested to rely on autophagic degradation of dysfunctional mitochondria or selective replication/transmission of non-deleterious variants. Thus, understanding the mechanisms regulating mitochondrial inheritance is important both to improve diagnosis and develop therapeutic tools for preventing transmission of mtDNA-encoded diseases. (AU)

Processo FAPESP: 16/07868-4 - Efeito do nocaute das mitofusinas em fibroblastos embrionários murinos sobre a herança de DNA mitocondrial deletério
Beneficiário:Carolina Habermann Macabelli
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 17/05899-2 - Efeito do nocaute das mitofusinas no oócito murino: implicações para a fertilidade e herança mitocondrial
Beneficiário:Marcos Roberto Chiaratti
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 12/50231-6 - Bases moleculares da herança mitocondrial: o papel da fusão mitocondrial
Beneficiário:Marcos Roberto Chiaratti
Linha de fomento: Auxílio à Pesquisa - Apoio a Jovens Pesquisadores
Processo FAPESP: 16/11942-5 - Efeito do nocaute da mitofusina 1 sobre a fertilidade de oócitos murinos
Beneficiário:Karen Freire Carvalho
Linha de fomento: Bolsas no Brasil - Mestrado
Processo FAPESP: 16/11935-9 - Efeito do nocaute da mitofusina 2 sobre a mitocôndria, o retículo endoplasmático e a mitofagia em oócitos murinos
Beneficiário:Bruna Martins Garcia
Linha de fomento: Bolsas no Brasil - Mestrado