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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Supramolecular cyclodextrin-based metal-organic frameworks as efficient carrier for anti-inflammatory drugs

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Autor(es):
Abucafy, Marina P. [1] ; Caetano, Bruno L. [1] ; Chiari-Andreo, Bruna G. [1, 2] ; Fonseca-Santos, Bruno [1] ; do Santos, Aline M. [1] ; Chorilli, Marlus [1] ; Chiavacci, Leila A. [1]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Sao Paulo State Univ UNESP, Dept Drugs & Med, Sch Pharmaceut Sci, Araraquara, SP - Brazil
[2] Univ Araraquara UNIARA, Dept Biol & Hlth Sci, Araraquara, SP - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS; v. 127, p. 112-119, JUN 2018.
Citações Web of Science: 14
Resumo

Drug delivery systems have been used to reduce adverse effects and improve the efficacy of therapies. Drug carriers have been developed over the years, but they have limitations. gamma-cyclodextrin-based metal-organic frameworks (gamma-CD-MOF) have significant advantages due to their biocompatibility and environmental safety, besides crystallinity and porosity. Herein, gamma-CD-MOFs were synthesised with different metals as nodes and investigated. Uniform mesoporous gamma-CD-MOFs were obtained and showed an absence of toxicity in HepG2 and Caco-2 cells. The longer controlled release was verified for gamma-CD-MOFs, with a maximum of 62% released in 12 h. An inflammation experiment was performed in mice and activity equivalent to the positive control was verified. gamma-KCD-MOFs and gamma-NaCD-MOFs reached activity after 6 h of administration, however this happened after 24 h in gamma-FeCD-MOFs, being more effective than the positive control. Considering the ability for drug entrapment, easy preparation and controlled release, this class of material allows potential applications in drug delivery systems. (AU)

Processo FAPESP: 14/10888-1 - Desenvolvimento e caracterização de redes metalo-orgânicas a base de ciclodextrina
Beneficiário:Marina Paiva Abuçafy
Linha de fomento: Bolsas no Brasil - Mestrado