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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Structural brain abnormalities in the common epilepsies assessed in a worldwide ENIGMA study

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Autor(es):
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Whelan, Christopher D. [1, 2] ; Altmann, Andre [3] ; Botia, Juan A. [4, 5] ; Jahanshad, Neda [1] ; Hibar, Derrek P. [1] ; Absil, Julie [6] ; Alhusaini, Saud [2, 7] ; Alvim, Marina K. M. [8] ; Auvinen, Pia [9, 10] ; Bartolini, Emanuele [11, 12] ; Bergo, Felipe P. G. [8] ; Bernardes, Tauana [8] ; Blackmon, Karen [13, 14] ; Braga, Barbara [8] ; Caligiuri, Maria Eugenia [15] ; Calvo, Anna [16] ; Carr, Sarah J. [17] ; Chen, Jian [18] ; Chen, Shuai [19, 20] ; Cherubini, Andrea [15] ; David, Philippe [6] ; Domin, Martin [21] ; Foley, Sonya [22] ; Franca, Wendy [8] ; Haaker, Gerrit [23, 24] ; Isaev, Dmitry [1] ; Keller, Simon S. [25] ; Kotikalapudi, Raviteja [26, 27] ; Kowalczyk, Magdalena A. [28] ; Kuzniecky, Ruben [13] ; Langner, Soenke [21] ; Lenge, Matteo [11] ; Leyden, Kelly M. [29, 30] ; Liu, Min [31] ; Loi, Richard Q. [29] ; Martin, Pascal [26] ; Mascalchi, Mario [32, 33] ; Morita, Marcia E. [8] ; Pariente, Jose C. [16] ; Rodriguez-Cruces, Raul [34] ; Rummel, Christian [35] ; Saavalainen, Taavi [9, 36] ; Semmelroch, Mira K. [28] ; Severino, Mariasavina [37] ; Thomas, Rhys H. [38, 39] ; Tondelli, Manuela [40] ; Tortora, Domenico [37] ; Vaudano, Anna Elisabetta [40] ; Vivash, Lucy [41, 42] ; von Podewils, Felix [43] ; Wagner, Jan [44] ; Weber, Bernd ; Yao, Yi [45] ; Yasuda, Clarissa L. [8] ; Zhang, Guohao [46] ; Bargallo, Nuria [16, 47] ; Bender, Benjamin [27] ; Bernasconi, Neda [31] ; Bernasconi, Andrea [31] ; Bernhardt, Boris C. [31, 48] ; Bluemcke, Ingmar [24] ; Carlson, Chad [49, 13] ; Cavalleri, Gianpiero L. [2, 50] ; Cendes, Fernando [8] ; Concha, Luis [34] ; Delanty, Norman [2, 50, 51] ; Depondt, Chantal [52] ; Devinsky, Orrin [13] ; Doherty, Colin P. [50, 53] ; Focke, Niels K. [54, 26] ; Gambardella, Antonio [15, 55] ; Guerrini, Renzo [11, 12] ; Hamandi, Khalid [38, 39] ; Jackson, Graeme D. [28, 56] ; Kalviainen, Reetta [9, 10] ; Kochunov, Peter [57] ; Kwan, Patrick [41] ; Labate, Angelo [15, 55] ; McDonald, Carrie R. [29, 30] ; Meletti, Stefano [40] ; O'Brien, Terence J. [41, 58] ; Ourselin, Sebastien [3] ; Richardson, Mark P. [17, 59] ; Striano, Pasquale [60] ; Thesen, Thomas [13, 14] ; Wiest, Roland [35] ; Zhang, Junsong [19, 20] ; Vezzani, Annamaria [61] ; Ryten, Mina [4, 5, 62] ; Thompson, Paul M. [1] ; Sisodiya, Sanjay M. [63, 64] ; Consortium, UK Brain Expression ; Grp, ENIGMA-Epilepsy Working
Número total de Autores: 93
Afiliação do(s) autor(es):
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[1] Univ So Calif, Mark & Mary Stevens Neuroimaging & Informat Inst, Imaging Genet Ctr, Los Angeles, CA - USA
[2] Royal Coll Surgeons Ireland, Dept Mol & Cellular Therapeut, Dublin - Ireland
[3] UCL, Translat Imaging Grp, Ctr Med Image Comp, London - England
[4] UCL, Inst Neurol, Reta Lila Weston Inst, London WC1N 3BG - England
[5] UCL, Inst Neurol, Dept Mol, London WC1N 3BG - England
[6] Univ Libre Bruxelles, Dept Radiol, Hop Erasme, B-1070 Brussels - Belgium
[7] McGill Univ, Montreal Neurol Inst, Dept Neurol & Neurosurg, Montreal, PQ - Canada
[8] Univ Estadual Campinas, Dept Neurol, Campinas - Brazil
[9] Univ Eastern Finland, Inst Clin Med Neurol, Kuopio - Finland
[10] Univ Kuopio, Dept Neurol, Epilepsy Ctr, Kuopio - Finland
[11] Meyer Univ Florence, Childrens Hosp A, Pediat Neurol Unit, Florence - Italy
[12] IRCCS Stella Maris Fdn, Pisa - Italy
[13] NYU, Sch Med, Dept Neurol, Comprehens Epilepsy Ctr, New York, NY - USA
[14] St Georges Univ, Dept Physiol Neurosci & Behav Sci, True Blue Point - Grenada
[15] CNR, Catanzaro - Italy
[16] IDIBAPS, Magnet Resonance Image Core Facil, Barcelona - Spain
[17] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Basic & Clin Neurosci, London - England
[18] Ohio State Univ, Dept Comp Sci & Engn, Columbus, OH 43210 - USA
[19] Xiamen Univ, Cognit Sci Dept, Xiamen - Peoples R China
[20] Fujian Key Lab Brain Iike Intelligent Syst, Fujian - Peoples R China
[21] Univ Med Greifswald, Inst Diagnost Radiol & Neuroradiol, Funct Imaging Unit, Greifswald - Germany
[22] Cardiff Univ, Brain Res Imaging Ctr, Sch Psychol, Cardiff, S Glam - Wales
[23] Univ Hosp, Dept Neurosurg, Freiburg - Germany
[24] Univ Hosp Erlangen, Dept Neuropathol, Erlangen - Germany
[25] Univ Liverpool, Inst Translat Med, Dept Mol & Clin Pharmacol, Liverpool, Merseyside - England
[26] Univ Tubingen, Hertie Inst Clin Brain Res, Dept Neurol & Epileptol, Tubingen - Germany
[27] Univ Tubingen, Dept Diagnost & Intervent Neuroradiol, Tubingen - Germany
[28] Florey Inst Neurosci & Mental Hlth, Austin Campus, Melbourne, Vic - Australia
[29] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 - USA
[30] Univ Calif San Diego, Multimodal Imaging Lab, San Diego, CA 92103 - USA
[31] McGill Univ, Montreal Neurol Inst & Hosp, Neuroimaging Epilepsy Lab, Montreal, PQ - Canada
[32] Childrens Hosp A Meyer, Neuroradiol Unit, Florence - Italy
[33] Univ Florence, Mario Serio Dept Expt & Clin Biomed Sci, Florence - Italy
[34] Univ Nacl Autonoma Mexico, Inst Neurobiol, Queretaro - Mexico
[35] Univ Bern, Inselspital, Univ Inst Diagnost & Intervent Neuroradiol, SCAN, Bern - Switzerland
[36] Cent Finland Cent Hosp, Med Imaging Unit, Jyvaskyla - Finland
[37] Ist Giannina Gaslini, Dept Head & Neck & Neurosci, Neuroradiol Unit, Genoa - Italy
[38] Inst Psychol Med & Clin Neurosci, Hadyn Ellis Bldg, Maindy Rd, Cardiff, S Glam - Wales
[39] Univ Wales Hosp, Dept Neurol, Cardiff, S Glam - Wales
[40] Univ Modena & Reggio Emilia, NOCSE Hosp, Dept Biomed Metab & Neural Sci, Modena - Italy
[41] Royal Melbourne Hosp, Dept Neurol, Parkville, Vic 3050 - Australia
[42] Univ Melbourne, Dept Med, Melbourne Brain Ctr, Parkville, Vic 3052 - Australia
[43] Univ Med Greifswald, Dept Neurol, Greifswald - Germany
[44] Philips Univ Marburg, Dept Neurol, Marburg - Germany
[45] Xiamen Univ, Affiliated Chenggong Hosp, Xiamen - Peoples R China
[46] Univ Maryland, Dept Comp Sci & Elect Engn, Baltimore, MD 21201 - USA
[47] Hosp Clin Barcelona, Ctr Diagnost Imatge CDIC, Barcelona - Spain
[48] McGill Univ, Montreal Neurol Inst & Hosp, Multimodal Imaging & Connectome Anal Lab, Montreal, PQ - Canada
[49] Med Coll Wisconsin, Dept Neurol, Milwaukee, WI 53226 - USA
[50] RCSI, FutureNeuro Res Ctr, Dublin - Ireland
[51] Beaumont Hosp, Div Neurol, Dublin 9 - Ireland
[52] Univ Libre Bruxelles, Dept Neurol, Hop Erasme, B-1070 Brussels - Belgium
[53] St James Hosp, Neurol Dept, Dublin 8 - Ireland
[54] Univ Gottingen, Dept Clin Neurophysiol, Gottingen - Germany
[55] Magna Graecia Univ Catanzaro, Inst Neurol, Catanzaro - Italy
[56] Univ Melbourne, Florey Dept Neurosci & Mental Hlth, Melbourne, Vic - Australia
[57] Univ Maryland, Sch Med, Maryland Psychiat Res Ctr, Dept Psychiat, Catonsville, MD 21228 - USA
[58] Univ Melbourne, Dept Med, Parkville, Vic 3052 - Australia
[59] Kings Coll Hosp London, Dept Neurol, London - England
[60] Univ Genoa, Dept Neurosci Rehabil Ophthalmol Genet Maternal &, Pediat Neurol & Muscular Dis Unit, Genoa - Italy
[61] Mario Negri Inst Pharmacol Res, Dept Neurosci, Via G La Masa 19, I-20156 Milan - Italy
[62] Kings Coll London, Dept Med & Mol Genet, London SE1 9RT - England
[63] UCL, Inst Neurol, Dept Clin & Expt Epilepsy, Box 29, Queen Sq, London WC1N 3BG - England
[64] Chalfont Ctr Epilepsy, Gerrards Cross, Bucks - England
Número total de Afiliações: 64
Tipo de documento: Artigo Científico
Fonte: BRAIN; v. 141, n. 2, p. 391-408, FEB 2018.
Citações Web of Science: 22
Resumo

Progressive functional decline in the epilepsies is largely unexplained. We formed the ENIGMA-Epilepsy consortium to understand factors that influence brain measures in epilepsy, pooling data from 24 research centres in 14 countries across Europe, North and South America, Asia, and Australia. Structural brain measures were extracted from MRI brain scans across 2149 individuals with epilepsy, divided into four epilepsy subgroups including idiopathic generalized epilepsies (n = 367), mesial temporal lobe epilepsies with hippocampal sclerosis (MTLE; left, n = 415; right, n = 339), and all other epilepsies in aggregate (n = 1026), and compared to 1727 matched healthy controls. We ranked brain structures in order of greatest differences between patients and controls, by meta-analysing effect sizes across 16 subcortical and 68 cortical brain regions. We also tested effects of duration of disease, age at onset, and age-by-diagnosis interactions on structural measures. We observed widespread patterns of altered subcortical volume and reduced cortical grey matter thickness. Compared to controls, all epilepsy groups showed lower volume in the right thalamus (Cohen's d = -0.24 to -0.73; P51.49 x 10(-4)), and lower thickness in the precentral gyri bilaterally (d = -0.34 to -0.52; P < 4.31 x 10(-6)). Both MTLE subgroups showed profound volume reduction in the ipsilateral hippocampus (d = -1.73 to -1.91, P < 1.4 x 10(-19)), and lower thickness in extrahippocampal cortical regions, including the precentral and paracentral gyri, compared to controls (d = -0.36 to -0.52; P < 1.49 x 10(-4)). Thickness differences of the ipsilateral temporopolar, parahippocampal, entorhinal, and fusiform gyri, contralateral pars triangularis, and bilateral precuneus, superior frontal and caudal middle frontal gyri were observed in left, but not right, MTLE (d = -0.29 to -0.54; P < 1.49 x 10(-4)). Contrastingly, thickness differences of the ipsilateral pars opercularis, and contralateral transverse temporal gyrus, were observed in right, but not left, MTLE (d = -0.27 to -0.51; P < 1.49 x 10(-4)). Lower subcortical volume and cortical thickness associated with a longer duration of epilepsy in the all-epilepsies, all-other-epilepsies, and right MTLE groups (beta, b < -0.0018; P < 1.49 x 10(-4)). In the largest neuroimaging study of epilepsy to date, we provide information on the common epilepsies that could not be realistically acquired in any other way. Our study provides a robust ranking of brain measures that can be further targeted for study in genetic and neuropathological studies. This worldwide initiative identifies patterns of shared grey matter reduction across epilepsy syndromes, and distinctive abnormalities between epilepsy syndromes, which inform our understanding of epilepsy as a network disorder, and indicate that certain epilepsy syndromes involve more widespread structural compromise than previously assumed. (AU)

Processo FAPESP: 13/07559-3 - Instituto Brasileiro de Neurociência e Neurotecnologia - BRAINN
Beneficiário:Fernando Cendes
Linha de fomento: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs