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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Serological and molecular markers of hepatitis E virus infection in HIV-infected patients in Brazil

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Autor(es):
Ferreira, A. C. [1] ; Gomes-Gouvea, Michele Soares [1] ; Lisboa-Neto, G. [2] ; Mendes-Correa, M. C. J. [2] ; Picone, C. M. [3] ; Salles, N. A. [4] ; Mendrone-Junior, A. [4] ; Carrilho, F. J. [1] ; Pinho, J. R. R. [5, 1]
Número total de Autores: 9
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP, Dept Gastroenterol, Lab Gastroenterol & Hepatol Trop LIM 07, Inst Med, Av Dr Eneas Carvalho Aguiar 500, BR-05403000 Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Hosp Clin HCFMUSP, Dept Doencas Infecciosas & Parasitarias, Lab Virol LIM 52, Inst Med Trop USP, Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med, Dept Doencas Infecciosas & Parasitarias, Sao Paulo, SP - Brazil
[4] Fundacao Prosangue Hemoctr Sao Paulo, Sao Paulo, SP - Brazil
[5] Hosp Israelita Albert Einstein, Sao Paulo, SP - Brazil
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: ARCHIVES OF VIROLOGY; v. 163, n. 1, p. 43-49, JAN 2018.
Citações Web of Science: 7
Resumo

In Brazil, the circulation of hepatitis E virus (HEV) has been demonstrated in distinct groups of individuals and some animals, but its prevalence among individuals with human immunodeficiency virus (HIV) infection is unknown. This study aimed to assess the frequency of serological and molecular HEV markers in individuals infected with HIV from So Paulo, Brazil. Serum and plasma samples of 354 HIV-infected patients collected between 2007 and 2013 were included. All samples were tested for anti-HEV IgG and IgM antibodies and HEV RNA. Anti-HEV IgG and IgM antibodies were detected in 10.7% (38/354) and 1.4% (5/354) of the samples, respectively. Both antibodies were detected simultaneously in only two samples. HEV RNA was not detected in any sample. There was no significant correlation of anti-HEV serological status (positivity to anti-HEV IgG and/or IgM) with sex, age, CD4(+) T cell count, HIV viral load, antiretroviral therapy, liver enzyme levels, or coinfection with hepatitis B virus and/or hepatitis C virus. Our study provides serological evidence of past and recent HEV infections in HIV-infected patients from So Paulo, Brazil. However, the occurrence of ongoing HEV infection appears be a rare event in this population. (AU)

Processo FAPESP: 12/21588-3 - Pesquisa de marcadores sorológicos e moleculares da infecção pelo vírus da hepatite e (HEV) em indivíduos portadores do vírus da imunodeficiência humana (HIV)
Beneficiário:Ariana Carolina Ferreira
Linha de fomento: Bolsas no Brasil - Mestrado
Processo FAPESP: 12/50504-2 - Pesquisa de marcadores sorológicos e moleculares da infecção pelo vírus da hepatite e (HEV) em diferentes grupos populacionais em São Paulo
Beneficiário:João Renato Rebello Pinho
Linha de fomento: Auxílio à Pesquisa - Regular