Chemotherapy of leishmaniasis: present challenges

Autor(es)

Uliana, Silvia R. B. ^[1] ; Trinconi, Cristiana T. ^[1] ; Coelho, Adriano C. ^{[2, 1]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Ciencias Biomed, Dept Parasitol, Ave Prof Lineu Prestes 1374, BR-05508000 Sao Paulo - Brazil

^[2] Univ Estadual Campinas, Inst Biol, Dept Biol Anim, Campinas, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: Parasitology; v. 145, n. 4, SI, p. 464-480, APR 2018.
• Citações Web of Science: 30

Resumo

Cutaneous and visceral leishmaniasis are amongst the most devastating infectious diseases of our time, affecting millions of people worldwide. The treatment of these serious diseases rely on a few chemotherapeutic agents, most of which are of parenteral use and induce severe side-effects. Furthermore, rates of treatment failure are high and have been linked to drug resistance in some areas. Here, we reviewed data on current chemotherapy practice in leishmaniasis. Drug resistance and mechanisms of resistance are described as well as the prospects for applying drug combinations for leishmaniasis chemotherapy. It is clear that efforts for discovering new drugs applicable to leishmaniasis chemotherapy are essential. The main aspects on the various steps of drug discovery in the field are discussed. (AU)

• Processo FAPESP: 15/23832-7 - Novas abordagens para superar as deficiências do tratamento de leishmaniose: concepção de modelo de leishmaniose visceral in vitro baseado na tecnologia de organs-on-a-chip e avaliação de estratégias para reverter resistência ao antimônio
• Beneficiário: Cristiana de Melo Trinconi Tronco
• Linha de fomento: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 15/09080-2 - Avaliação de candidatos a fármacos para o tratamento de leishmaniose no Brasil
• Beneficiário: Silvia Reni Bortolin Uliana
• Linha de fomento: Auxílio à Pesquisa - Regular
• Processo FAPESP: 12/14629-5 - Mecanismos de ação e resistência à Miltefosina Leishmania spp.
• Beneficiário: Adriano Cappellazzo Coelho
• Linha de fomento: Bolsas no Brasil - Pós-Doutorado