S-nitrosoglutathione-containing chitosan nanoparticles dispersed in Pluronic F-127 hydrogel: Potential uses in topical applications

Autor(es)

Pelegrino, Milena T. ^{[1, 2]} ; de Araujo, Daniele R. ^{[1, 2]} ; Seabra, Amedea B. ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Fed Univ ABC, Ctr Nat & Human Sci, Av Estados 5001, BR-09210580 Santo Andre, SP - Brazil

^[2] Fed Univ ABC UFABC, Nanomed Res Unit NANOMED, Santo Andre, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY; v. 43, p. 211-220, FEB 2018.
• Citações Web of Science: 7

Resumo

The aim of this study was to prepare nitric oxide (NO) releasing nanoparticle/hydrogel with potential uses in topical applications. NO is a signaling molecule in skin. It controls the dermal blood flow, skin defense, and tissue repair. There is an interest for designing topical formulations that release NO/NO donors directly at the desired application site. S-nitrosoglutathione (GSNO), a NO donor, was incorporated into chitosan nanoparticles (CS NPs) (hydrodynamic size of 112.2 +/- 2.22 nm). Free GSNO or GSNO-containing CS NPs were incorporated in Pluronic F-127 (PL) hydrogels. The purpose of this study was to combine the advantages of CS NPs (as a drug delivery system with mucoadhesive properties) and a PL hydrogel, which permits a prolonged contact time for the NO donor on the mucosal/skin surfaces. Rheological measurements were performed to determine the sol-gel transition temperature, the rheological parameters, and the viscosity. The polymeric matrices spontaneously released free NO. GSNO diffusion from the polymeric matrices was evaluated using a diffusion system. The results indicate that the incorporation of GSNO-CS NPs into a PL hydrogel may find important dermatological applications due to their mechanical properties and their ability to release therapeutic and sustained amounts of NO at the desired application site. (AU)

• Processo FAPESP: 16/10347-6 - Nanopartículas contendo S-nitrosotióis: Síntese, caracterização, ensaios de citotoxicidade e aplicações
• Beneficiário: Amedea Barozzi Seabra
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 15/00393-8 - Nanopartículas poliméricas doadoras de óxido nítrico para aplicações tópicas
• Beneficiário: Milena Trevisan Pelegrino
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 14/13913-7 - Preparação, caracterização e ensaios biomédicos de sistemas nanoparticulados mono e bimetálicos
• Beneficiário: Paula Silvia Haddad Ferreira
• Modalidade de apoio: Auxílio à Pesquisa - Regular