Adipocytes role in the bone marrow niche

Autor(es)

Guerra, Daniel A. P. ^[1] ; Paiva, Ana E. ^[1] ; Sena, Isadora F. G. ^[1] ; Azevedo, Patrick O. ^[1] ; Batista, Jr., Miguel Luiz ^[2] ; Mintz, Akiva ^[3] ; Birbrair, Alexander ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Minas Gerais, Dept Pathol, Belo Horizonte, MG - Brazil

^[2] Univ Mogi das Cruzes, Lab Adipose Tissue Biol, Sao Paulo - Brazil

^[3] Columbia Univ, Med Ctr, Dept Radiol, New York, NY - USA

• Tipo de documento: Carta
• Fonte: Cytometry Part A; v. 93A, n. 2, p. 167-171, FEB 2018.
• Citações Web of Science: 12

Resumo

Adipocyte infiltration in the bone marrow follows chemotherapy or irradiation. Previous studies indicate that bone marrow fat cells inhibit hematopoietic stem cell function. Recently, Zhou et al. (2017) using state-of-the-art techniques, including sophisticated Cre/loxP technologies, confocal microscopy, in vivo lineage-tracing, flow cytometry, and bone marrow transplantation, reveal that adipocytes promote hematopoietic recovery after irradiation. This study challenges the current view of adipocytes as negative regulators of the hematopoietic stem cells niche, and reopens the discussion about adipocytes' roles in the bone marrow. Strikingly, genetic deletion of stem cell factor specifically from adipocytes leads to deficiency in hematopoietic stem cells, and reduces animal survival after myeloablation, The emerging knowledge from this research will be important for the treatment of multiple hematologic disorders. (c) 2017 International Society for Advancement of Cytometry (AU)

• Processo FAPESP: 15/19259-0 - Repercussões do remodelamento do tecido adiposo durante a síndrome de caquexia em pacientes com câncer gastrointestinal: potencial envolvimento do receptor TLR4 na modulação do browning no TAB
• Beneficiário: Miguel Luiz Batista Junior
• Linha de fomento: Auxílio à Pesquisa - Regular
• Processo FAPESP: 10/51078-1 - Bases moleculares da caquexia: adipogênese e remodelagem da matriz extracelular do tecido adiposo branco de pacientes com câncer gastrointestinal
• Beneficiário: Miguel Luiz Batista Junior
• Linha de fomento: Auxílio à Pesquisa - Apoio a Jovens Pesquisadores