Malaria during pregnancy and newborn outcome in an unstable transmission area in Brazil: A population-based record linkage study

Autor(es)

Dombrowski, Jamille Gregorio ^[1] ; de Souza, Rodrigo Medeiros ^[2] ; Mendes Silva, Natercia Regina ^[1] ; Barateiro, Andre ^[1] ; Epiphanio, Sabrina ^[3] ; Goncalves, Ligia Antunes ^[1] ; Farias Marinho, Claudio Romero ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Biomed Sci, Dept Parasitol, Sao Paulo - Brazil

^[2] Univ Fed Acre, Multidisciplinary Ctr, Acre - Brazil

^[3] Univ Sao Paulo, Sch Pharmaceut Sci, Dept Clin & Toxicol Anal, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: PLoS One; v. 13, n. 6 JUN 21 2018.
• Citações Web of Science: 1

Resumo

Background Malaria in pregnancy (MiP) is one of the major causes of mortality and morbidity in tropical regions, causing maternal anemia, intrauterine growth retardation, preterm birth, and low birth weight (LBW). The integration of the information systems on pregnancy and malaria could prove to be a useful method of improved decision making for better maternal-child health. Methods A population-based observational study acquired information retrospectively from all live births that occurred between 2006 and 2014 in Cruzeiro do Sul (Acre, Brazil). Social and clinical data of the mother and newborn was extracted from the Information System of Live Births. Malaria episodes information was obtained from the Brazilian Epidemiological Surveillance Information System Malaria. A deterministic record linkage was performed to assess malaria impact on pregnancy. Results The studied population presented a malaria incidence of 8.9% (1283 pregnant women infected), of which 63.9% infected by Plasmodium (P.) vivax. Reduction of newborn birth weight at term (small for gestational age (SGA) and LBW) has been found associated with P. vivax infection during pregnancy (SGA-OR 1.24, 95% CI 1.02-1.52, p = 0.035; term LBW OR 1.39, 95% CI 1.03-1.88, p = 0.033). Additionally, P. falciparum infection during pregnancy has been found to be associated with preterm births (OR 1.54, 95% CI 1.09-2.18, p = 0.016), which is related with late preterm births (OR 1.59, 95% CI 1.11-2.27, p = 0.011). Conclusions Despite the decrease of malaria cases during the evaluation period and regardless of Plasmodium species, we present evidence of the deleterious effects of MiP in a low transmission area in the Amazonian region. (AU)

• Processo FAPESP: 15/06106-0 - O papel dos inflamassomas na patogênese da malária associada à gravidez: efeitos e mecanismos
• Beneficiário: Cláudio Romero Farias Marinho
• Modalidade de apoio: Auxílio à Pesquisa - Pesquisador Visitante - Internacional
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• Beneficiário: Jamille Gregório Dombrowski
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
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• Beneficiário: Sabrina Epiphanio
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 14/09964-5 - O papel dos inflamassomas na patogênese da malária associada à gravidez: efeitos e mecanismos
• Beneficiário: Cláudio Romero Farias Marinho
• Modalidade de apoio: Auxílio à Pesquisa - Regular
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• Beneficiário: Cláudio Romero Farias Marinho
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores