Heterocyclic N-oxides - A Promising Class of Agents against Tuberculosis, Malaria and Neglected Tropical Diseases

Autor(es)

dos Santos Fernandes, Guilherme Felipe ^{[1, 2]} ; Pavan, Aline Renata ^[2] ; dos Santos, Jean Leandro ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ UNESP, Inst Chem, Araraquara - Brazil

^[2] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Araraquara - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: CURRENT PHARMACEUTICAL DESIGN; v. 24, n. 12, p. 1325-1340, 2018.
• Citações Web of Science: 2

Resumo

Heterocyclic N-oxides have emerged as promising agents against a number of diseases and disorders, especially infectious diseases. This review analyzes the emergence and development of this scaffold in the medicinal chemistry, focusing mainly on the discovery of new heterocyclic N-oxide compounds with potent activity against tuberculosis, malaria and neglected tropical diseases (i.e. leishmaniasis and Chagas disease). A number of heterocyclic N-oxides are described herein, nevertheless, the following chemical classes deserve to be highlighted due to a large number of reports in the literature about their promising pharmacological effects: furoxan, benzofuroxan, quinoxaline 1,4-di-N-oxide, indolone N-oxide and benzimidazole N-oxide. In order to describe those most promising compounds, we included in this review only those most biologically active heterocyclic N-oxide published since 2000. (AU)

• Processo FAPESP: 15/21252-3 - Síntese e Avaliação Farmacológica de novos análogos da talidomida/pomalidomida reguladores de mecanismos epigenéticos
• Beneficiário: Aline Renata Pavan
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 16/09502-7 - Planejamento, síntese e atividade antituberculose de novas oxazolidinonas úteis ao tratamento da tuberculose multirresistente
• Beneficiário: Guilherme Felipe dos Santos Fernandes
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 15/19531-1 - Inibição de histona deacetilase (HDAC-1 e HDAC-2) como alvos para indução de Hemoglobina Fetal na Anemia Falciforme
• Beneficiário: Jean Leandro dos Santos
• Modalidade de apoio: Auxílio à Pesquisa - Regular