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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Heparan Sulfate Proteoglycans in Human Colorectal Cancer

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Autor(es):
Vicente, Carolina Meloni [1] ; da Silva, Daiana Aparecida [1] ; Sartorio, Priscila Veronica [2] ; Silva, Tiago Donizetti [3] ; Saad, Sarhan Sydney [4] ; Nader, Helena Bonciani [1] ; Forones, Nora Manoukian [3] ; Toma, Leny [1]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo, Escola Paulista Med, Disciplina Biol Mol, Rua Tres de Maio, 100 4 Andar, Sao Paulo, SP - Brazil
[2] Univ Fed Sao Paulo, Escola Paulista Med, Disciplina Farmacol Celular, Rua Tres de Maio, 100 4 Andar, Sao Paulo, SP - Brazil
[3] Univ Fed Sao Paulo, Escola Paulista Med, Disciplina Gastroenterol, Rua Loefgreen 1726, Sao Paulo, SP - Brazil
[4] Univ Fed Sao Paulo, Escola Paulista Med, Disciplina Gastroenterol Cirurg, Rua Napoleao Barros, 715 2 Andar, Sao Paulo, SP - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo de Revisão
Fonte: ANALYTICAL CELLULAR PATHOLOGY; 2018.
Citações Web of Science: 3
Resumo

Colorectal cancer is the third most common cancer worldwide, accounting for more than 610,000 mortalities every year. Prognosis of patients is highly dependent on the disease stage at diagnosis. Therefore, it is crucial to investigate molecules involved in colorectal cancer tumorigenesis, with possible use as tumor markers. Heparan sulfate proteoglycans are complex molecules present in the cell membrane and extracellular matrix, which play vital roles in cell adhesion, migration, proliferation, and signaling pathways. In colorectal cancer, the cell surface proteoglycan syndecan-2 is upregulated and increases cell migration. Moreover, expression of syndecan-1 and syndecan-4, generally antitumor molecules, is reduced. Levels of glypicans and perlecan are also altered in colorectal cancer; however, their role in tumor progression is not fully understood. In addition, studies have reported increased heparan sulfate remodeling enzymes, as the endosulfatases. Therefore, heparan sulfate proteoglycans are candidate molecules to clarify colorectal cancer tumorigenesis, as well as important targets to therapy and diagnosis. (AU)

Processo FAPESP: 16/18066-6 - O papel dos microdomínios 6-O-sulfatados de proteoglicanos na biologia tumoral e tecidual.
Beneficiário:Leny Toma
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 15/03964-6 - Glicosaminoglicanos e proteoglicanos: relação estrutura e função
Beneficiário:Helena Bonciani Nader
Linha de fomento: Auxílio à Pesquisa - Temático