Interleukin 6 and 10 Serum Levels and Genetic Polymorphisms in Children with Down Syndrome

Autor(es)

Mattos, Marlon Fraga ^[1] ; Biselli-Chicote, Patricia Matos ^[1] ; Biselli, Joice Matos ^[2] ; da Silva Assembleia, Thiago Luis ^[1] ; Goloni-Bertollo, Eny Maria ^[1] ; Pavarino, Erika Cristina ^[1]

Afiliação do(s) autor(es)

^[1] Fac Med Sao Jose Do Rio Preto, Unidade Pesquisa Genet & Biol Mol, Sao Jose Do Rio Preto, SP - Brazil

^[2] Univ Estadual Paulista, Inst Biociencias Letras & Ciencias Exatas, Sao Jose Do Rio Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Mediators of Inflammation; 2018.
• Citações Web of Science: 1

Resumo

Immunological impairment is a condition that is often observed in individuals with Down syndrome (DS). The immune response is modulated by pro- and anti-inflammatory cytokines whose expressions could be influenced by genetic polymorphisms. The present study was aimed at evaluating the frequencies of -174G>C, -572G>C, and -597G>A polymorphisms in the interleukin 6 (IL-6) gene and -592C>A, -1082A>G, and -819C>T polymorphisms in the IL-10 gene and the IL-6 and IL-10 serum levels in healthy individuals with and without DS. The authors also aimed to investigate the impact of the genotypes on the interleukin concentrations. The genetic polymorphisms were investigated in 200 DS individuals and 200 controls without DS. The serum measurement of IL-6 and IL-10 was performed in a subgroup (54 cases and 54 controls) by enzyme-linked immunosorbent assay (ELISA). The frequencies of the polymorphisms and haplotypes evaluated were not different between individuals with and without DS. IL-10 concentration was higher in DS children but was not influenced by IL-10 gene polymorphisms. IL-6 genotypes had no influence on IL-6 serum levels. The IL-10 serum levels are increased in DS individuals, but IL-10 polymorphisms are not the main factors that influence the IL-10 expression in DS. (AU)

• Processo FAPESP: 14/26218-5 - Influência de polimorfismos genéticos nas concentrações de interleucinas e no risco para cardiopatias congênitas em indivíduos com Síndrome de Down
• Beneficiário: Erika Cristina Pavarino
• Linha de fomento: Auxílio à Pesquisa - Regular