Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Cognitive Reserve Relates to Functional Network Efficiency in Alzheimer's Disease

Texto completo
Autor(es):
Mostrar menos -
Weiler, Marina [1, 2] ; Casseb, Raphael Fernandes [1, 2] ; de Campos, Brunno Machado [1] ; de Ligo Teixeira, Camila Vieira [1] ; Mac Knight Carletti-Cassani, Ana Flavia [1] ; Vicentini, Jessica Elias [1] ; Cardoso Magalhaes, Thamires Naela [1] ; de Almeira, Debora Queiroz [1] ; Talib, Leda Leme [3] ; Forlenza, Orestes Vicente [3] ; Figueredo Balthazar, Marcio Luiz [1] ; Castellano, Gabriela [2, 4]
Número total de Autores: 12
Afiliação do(s) autor(es):
[1] Univ Campinas UNICAMP, Sch Med Sci, Neuroimaging Lab, Campinas, SP - Brazil
[2] Univ Campinas UNICAMP, Cosm Rays & Chronol Dept, Neurophys Grp, Inst Phys Gleb Wataghin, Campinas, SP - Brazil
[3] Univ Sao Paulo, Fac Med, Hosp Clin, Lab Neurociencias LIM 27, Dept & Inst Psiquiatria, Sao Paulo - Brazil
[4] Brazilian Inst Neurosci & Neurotechnol BRAINN, Campinas, SP - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: FRONTIERS IN AGING NEUROSCIENCE; v. 10, AUG 21 2018.
Citações Web of Science: 1
Resumo

Alzheimer's disease (AD) is the most common form of dementia, with no means of cure or prevention. The presence of abnormal disease-related proteins in the population is, in turn, much more common than the incidence of dementia. In this context, the cognitive reserve (CR) hypothesis has been proposed to explain the discontinuity between pathophysiological and clinical expression of AD, suggesting that CR mitigates the effects of pathology on clinical expression and cognition. fMRI studies of the human connectome have recently reported that AD patients present diminished functional efficiency in resting-state networks, leading to a loss in information flow and cognitive processing. No study has investigated, however, whether CR modifies the effects of the pathology in functional network efficiency in AD patients. We analyzed the relationship between CR, pathophysiology and network efficiency, and whether CR modifies the relationship between them. Fourteen mild AD, 28 amnestic mild cognitive impairment (aMCI) due to AD, and 28 controls were enrolled. We used education to measure CR, cerebrospinal fluid (CSF) biomarkers to evaluate pathophysiology, and graph metrics to measure network efficiency. We found no relationship between CR and CSF biomarkers; CR was related to higher network efficiency in all groups; and abnormal levels of CSF protein biomarkers were related to more efficient networks in the AD group. Education modified the effects of tau-related pathology in the aMCI and mild AD groups. Although higher CR might not protect individuals from developing AD pathophysiology, AD patients with higher CR are better able to cope with the effects of pathology-presenting more efficient networks despite pathology burden. The present study highlights that interventions focusing on cognitive stimulation might be useful to slow age-related cognitive decline or dementia and lengthen healthy aging. (AU)

Processo FAPESP: 13/07559-3 - Instituto Brasileiro de Neurociência e Neurotecnologia - BRAINN
Beneficiário:Fernando Cendes
Linha de fomento: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
Processo FAPESP: 15/06163-4 - A relação das reservas cerebral e cognitiva na conectividade de redes neurofuncionais em Doença de Alzheimer, considerando-se a presença do alelo APOE 4 e biomarcadores liquóricos
Beneficiário:Marina Weiler
Linha de fomento: Bolsas no Brasil - Pós-Doutorado