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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Hepatitis C viral load in HCV-monoinfected and HCV/HIV-1-, HCV/HTLV-1/-2-, and HCV/HIV/HTLV-1/-2-co-infected patients from Sao Paulo, Brazil

Texto completo
Autor(es):
Alves, Fabiana Aparecida [1] ; Campos, Karoline Rodrigues [1] ; Lemos, Marcilio Figueiredo [2] ; Moreira, Regina Celia [2] ; Caterino-de-Araujo, Adele [1]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Secretaria Estado Saude Sao Paulo, Coordenadoria Controle Doencas, Inst Adolfo Lutz, Ctr Imunol, Lab Pesquisa HTLV, Sao Paulo, SP - Brazil
[2] Secretaria Estado Saude Sao Paulo, Coordenadoria Controle Doencas, Inst Adolfo Lutz, Lab Hepatites Virais, Ctr Virol, Nucleo Doencas Transmissao Sanguinea &, Sao Paulo, SP - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: Brazilian Journal of Infectious Diseases; v. 22, n. 2, p. 123-128, MAR-APR 2018.
Citações Web of Science: 1
Resumo

Co-infections of hepatitis C virus (HCV) and either human immunodeficiency virus type 1 (HIV-1), human T-cell lymphotropic virus type 1 (HTLV-1) or type 2 (HTLV-2) have been described as having an impact on HCV viremia and subsequent disease progression. HCV load in serum samples from 622 patients (343 males, 279 females; median age 50.8 years) from Sao Paulo/southeast Brazil was analyzed using the Abbott Real Time HCV assay (Abbott Molecular Inc., IL, USA). Samples were obtained from HCV-monoinfected (n = 548), HCV/HIV-1- (n = 41), HCV/HTLV-1- (n =16), HCV/HTLV-2- (n = 8), HCV/HIV/HTLV-1- (n =4), and HCV/HIV/HTLV-2-co-infected (n = 5) patients, and results were compared among the groups and according to sex. The median HCV load in HCV-monoinfected patients was 5.23 log(10) IU/mL and 0.31 log(10) higher in men than in women. Increases in viral load of 0.51 log(10), 0.54 log(10), and 1.43 log(10 )IU/mL were detected in HCV/HIV-1-, HCV/HTLV-1- and HCV/HIV/HTLV1-co-infected individuals, respectively, compared with HCV-monoinfected counterparts. In contrast, compared to HCV/HIV co-infected patients, HCV/HTLV-2-co-infected patients had an HCV load of 5.0 log(10) IU/mL, whereas HCV/HIV/HTLV-2-co-infected patients had a median load 0.37 log(10) IU/mL lower. Significant differences in HCV loads were detected, with males and HCV/HIV-1- and HCV/HIV/HTLV-1-co-infected patients presenting the highest values. Conversely, females and HCV/HTLV-2-co-infected patients exhibited lower HCV loads. Overall, HCV viremia is increased in HIV and/or HTLV-1-co-infection and decreased in HTLV-2 co-infection. (C) 2018 Sociedade Brasileira de Infectologia. Published by Elsevier Editora Ltda. (AU)

Processo FAPESP: 16/03654-0 - Marcadores genéticos virais e do hospedeiro que podem influenciar o curso da infecção pelo HIV-1 e da coinfecção HIV-1/HTLV-1 e HIV-1/HTLV-2
Beneficiário:Adele Caterino de Araújo
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 12/51220-8 - Vigilância e diagnóstico de infecção por HTLV-1 e HTLV-2 em indivíduos infectados pelo HIV (vidiHIV/HTLV)
Beneficiário:Adele Caterino de Araújo
Linha de fomento: Auxílio à Pesquisa - Pesquisa em Políticas Públicas para o SUS