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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Low dose of chlorine exposure exacerbates nasal and pulmonary allergic inflammation in mice

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Autor(es):
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de Genaro, Isabella Santos [1, 2] ; de Almeida, Francine Maria [1] ; Hizume-Kunzler, Deborah Camargo [1, 3] ; Moriya, Henrique Takachi [4] ; Silva, Ronaldo Aparecido [1] ; Goncalves Cruz, Joao Carlos [5] ; Lopes, Renan Boeira [5] ; Righetti, Renato Fraga [6, 1] ; Vieira, Rodolfo de Paula [7, 8] ; Saiki, Mitiko [9] ; Martins, Milton Arruda [1] ; Lopes Calvo Tiberio, Iolanda de Fatima [1] ; Arantes-Costa, Fernanda Magalhaes [1] ; Saraiva-Romanholo, Beatriz Mangueira [5, 1, 2]
Número total de Autores: 14
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Sch Med, Dept Med LIM 20, Sao Paulo - Brazil
[2] Publ Employee Sao Paulo Hosp IAMSPE, Sao Paulo - Brazil
[3] Univ Estado Santa Catarina, Dept Phys Therapy LaPEx, Florianopolis, SC - Brazil
[4] Univ Sao Paulo, Escola Politecn, Biomed Engn Lab, Sao Paulo - Brazil
[5] Univ City Sao Paulo UNICID, Sao Paulo - Brazil
[6] Sirio Libanes Hosp, Sao Paulo - Brazil
[7] Univ Brasil, Postgrad Program Bioengn, Sao Paulo - Brazil
[8] Brazilian Inst Teaching & Res Pulm & Exercise Imm, Sao Jose Dos Campos - Brazil
[9] IPEN CNEN SP, Nucl & Energy Res Inst, Sao Paulo - Brazil
Número total de Afiliações: 9
Tipo de documento: Artigo Científico
Fonte: SCIENTIFIC REPORTS; v. 8, AUG 22 2018.
Citações Web of Science: 2
Resumo

Work-exacerbated asthma (WEA) is defined as preexisting asthma that worsens with exposure to irritants {[}e.g., chlorine (Cl-2) derivatives] in the workplace. The maximum allowable concentration in the workplace of Cl-2 exposure is 3 mg/m(3) (described in OSHA). We investigated in an experimental asthma model in mice the effects of a single exposure to a sodium hypochlorite dose with this allowed chlorine concentration and a tenfold higher dose. Acute chlorine exposure at 3.3 mg/m(3) in the OVA-sensitized group increased eosinophils in the peribronquial infiltrate, cytokine production, nasal mucus production and the number of iNOS positive cells in the distal lung compared to only sensitized mice. The exposure to a higher dose of 33.3 mg/m(3) in the OVA-sensitized group resulted in an increase in respiratory system elastance, in the total and differential numbers of inflammatory cells in bronchoalveolar lavage fluid, IL-4, IL-5, and IL-17 in the lungs, eosinophils in peribronquial infiltrate and mucus content in nasal compared to non-exposed and sensitized animals. In this asthma model, chorine exposures at an allowable dose, contributed to the potentiation of Th2 responses. The functional alterations were associated with increased iNOS and ROCK-2 activation in the distal lung. (AU)

Processo FAPESP: 12/15165-2 - Papel da sinalização purinérgica e da sinalização SOCS-JAK-STAT nos efeitos antiinflamatórios do treinamento aeróbio em modelos experimentais de asma e em indivíduos asmáticos
Beneficiário:Rodolfo de Paula Vieira
Linha de fomento: Auxílio à Pesquisa - Apoio a Jovens Pesquisadores
Processo FAPESP: 09/53904-9 - Efeitos do ambiente e do estilo de vida sobre a asma e a doença pulmonar obstrutiva crônica: estudos experimentais e clínicos
Beneficiário:Milton de Arruda Martins
Linha de fomento: Auxílio à Pesquisa - Temático