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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Codon adaptation biases among sylvatic and urban genotypes of Dengue virus type 2

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Autor(es):
Cunha, Marielton dos Passos [1] ; Ortiz-Baez, Ayda Susana [2, 1] ; de Melo Freire, Caio Cesar [3] ; de Andrade Zanotto, Paolo Marinho [1]
Número total de Autores: 4
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Biomed Sci Inst, Dept Microbiol, Lab Mol Evolut & Bioinformat, Sao Paulo - Brazil
[2] Inst Invest Recursos Biol Alexander von Humboldt, Bogota - Colombia
[3] UFSCar Fed Univ Sao Carlos, Dept Genet & Evolut, Sao Paulo - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: INFECTION GENETICS AND EVOLUTION; v. 64, p. 207-211, OCT 2018.
Citações Web of Science: 1
Resumo

Dengue virus (DENV) emerged from the sylvatic environment and colonized urban settings, being sustained in a human-Aedes-human transmission chain, mainly by the bites of females of the anthropophilic species Aedes aegypti. Herein, we sought evidence for fine-tuning in viral codon usage, possibly due to viral adaptation to human transmission. We compared the codon adaptation of DENV serotype 2 (DENV-2) genotypes from urban and sylvatic habitats and tried to correlate the findings with key evolutionary determinants. We found that DENV-2 codons of urban and sylvatic genotypes had a higher CAI to humans than to Ae. aegypti. Remarkably, we found no significant differences in codon adaptation to human between urban American/Asian and sylvatic DENV-2 genotypes. Moreover, CAI values were significantly different, when comparing all genotypes to Ae. aegypti codon preferences, with lower values for sylvatic than urban genotypes. In summary, our findings suggest the presence of a molecular signature among the genotypes that circulate in sylvatic and urban environments, and may help explain the trafficking of DENV-2 strains to an urban cycle. (AU)

Processo FAPESP: 13/25434-3 - Diversidade genética intra-hospedeiro do vírus da dengue tipo 4 no município de Guarujá, Estado de São Paulo.
Beneficiário:Ayda Susana Ortiz Baez
Linha de fomento: Bolsas no Brasil - Mestrado
Processo FAPESP: 16/08204-2 - Diversidade genética e filodinâmica dos arbovírus emergentes e reemergentes (DENV, ZIKV e CHIKV) nas regiões Nordeste e Sudeste do Brasil, 2014-2016
Beneficiário:Marielton dos Passos Cunha
Linha de fomento: Bolsas no Brasil - Doutorado