Role of Histamine in Modulating the Immune Response and Inflammation

Autor(es)

Calvielli Castelo Branco, Anna Claudia ^[1] ; Yamada Yoshikawa, Fabio Seiti ^[1] ; Pietrobon, Anna Julia ^[1] ; Sato, Maria Notomi ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Med, Lab Dermatol & Immunodeficiencies, LIM 56, Trop Med Inst, Dept Dermatol, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: Mediators of Inflammation; 2018.
• Citações Web of Science: 11

Resumo

Inflammatory mediators, including cytokines, histamine, bradykinin, prostaglandins, and leukotrienes, impact the immune system, usually as proinflammatory factors. Other mediators act as regulatory components to establish homeostasis after injury or prevent the inflammatory process. Histamine, a biogenic vasoactive amine, causes symptoms such as allergies and has a pleiotropic effect that is dependent on its interaction with its four histamine receptors. In this review, we discuss the dualistic effects of histamine: how histamine affects inflammation of the immune system through the activation of intracellular pathways that induce the production of inflammatory mediators and cytokines in different immune cells and how histamine exerts regulatory functions in innate and adaptive immune responses. We also evaluate the interactions between these effects. (AU)

• Processo FAPESP: 12/16524-6 - Efeito da histamina na ativação de células dendríticas e células TCD4+ mediado por agonistas de receptores toll-like em recém-natos
• Beneficiário: Maria Notomi Sato
• Linha de fomento: Auxílio à Pesquisa - Regular