Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Degradation of diclofenac by electron beam irradiaton: Toxicitiy removal, by-products identification and effect of another pharmaceutical compound

Texto completo
Autor(es):
Tominaga, Flavio Kiyoshi [1] ; dos Santos Batista, Ana Paula [2] ; Silva Costa Teixeira, Antonio Carlos [2] ; Borrely, Sueli Ivone [1]
Número total de Autores: 4
Afiliação do(s) autor(es):
[1] Radiat Technol Ctr IPEN CNEN SP, Nucl & Energy Res Inst, Av Prof Lineu Prestes 2242, BR-05508000 Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Chem Syst Engn Ctr, Dept Chem Engn, Res Grp Adv Oxidat Proc, Av Prof Luciano Gualberto 380, BR-05508010 Sao Paulo, SP - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING; v. 6, n. 4, p. 4605-4611, AUG 2018.
Citações Web of Science: 0
Resumo

Water contamination by the anti-inflammatory drug diclofenac (DCF) is a consequence of its incomplete removal in wastewater and sewage treatment plants, which is potentialized by interactions with other pharmaceutical contaminants. In this context, electron beam irradiation (EBI) has been considered a clean technology for degrading pharmaceutical compounds in water. Nevertheless, the identification of DCF by-products and their correlation with biological recalcitrance and acute toxicity are poorly understood. In this study, the V. fischeri test was used to characterize DCF toxicity in the absence and presence of fluoxetine (FLX), prior and after irradiation. The results showed complete DCF degradation at low dose (5 kGy). DCF concentration followed pseudo first-order decay with respect to the absorbed, with k(0) = (1.33 +/- 0.10) kGy(-1) (DCF) and k(0) = (0.90 +/- 0.12) kGy(-1) (DCF + FLX). In contrast, negligible TOC removal was observed even at 7.5 kGy, with the formation of recalcitrant, non-biodegradable by-products, as also suggested by the respirometry test. Despite that, the toxicity of the DCF solution diminished from (19.6 +/- 1.6) TU to (6.2 +/- 2.3) TU, and from (6.8 +/- 0.9) TU to (3.1 +/- 0.2) TU, in the absence and presence of FLX, respectively, after irradiation up to 5 kGy. Four of the eleven by-products identified by direct-injection MS were easily degraded by EBI, and one (C13H14ClNO5) was considered the least recalcitrant but the most toxic. Based on these results, a possible DCF degradation pathway is proposed, involving hydroxylation and oxidation of aromatic rings, dehalogenation and C - N bond cleavage. (AU)

Processo FAPESP: 13/50218-2 - CEPEMA - Centro Cooperativo em Engenharia Ambiental
Beneficiário:Claudio Augusto Oller do Nascimento
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 14/17996-4 - EMU concedido no processo 2013/50218-2: HPLC Cromatógrafo Líquido de Alta Eficiência
Beneficiário:Claudio Augusto Oller do Nascimento
Linha de fomento: Auxílio à Pesquisa - Programa Equipamentos Multiusuários