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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

beta-Adrenoceptors Trigger Melatonin Synthesis in Phagocytes

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Autor(es):
Pires-Lapa, Marco A. [1] ; Carvalho-Sousa, Claudia E. [1] ; Cecon, Erika [1] ; Fernandes, Pedro A. [2] ; Markus, Regina P. [1]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Inst Biosci, Lab Chronopharmacol, Deartment Physiol, BR-05508900 Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Biosci, Dept Physiol, Lab Neuroimmunoendocrinol, BR-05508900 Sao Paulo - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 19, n. 8 AUG 2018.
Citações Web of Science: 9
Resumo

Melatonin (5-methoxy-N-acetylserotonin), the pineal hormone, is also synthesized by immune-competent cells. The pineal hormone signals darkness, while melatonin synthesized on demand by activated macrophages at any hour of the day acts locally, favoring regulatory/tolerant phenotypes. Activation of beta-adrenoceptors in pinealocytes is the main route for triggering melatonin synthesis. However, despite the well-known role of beta-adrenoceptors in the resolution macrophage phenotype (M2), and the relevance of macrophage synthesized melatonin in facilitating phagocytic activity, there is no information regarding whether activation of beta-adrenoceptors would induce melatonin synthesis by monocytes. Here we show that catecholamines stimulate melatonin synthesis in bone marrow-derived dendritic cells and RAW 264.7 macrophages. Activation of beta-adrenoceptors promotes the synthesis of melatonin by stimulating cyclic AMP/protein kinase A (PKA) pathway and by activating the nuclear translocation of NF-kappa B. Considering the great number of macrophages around sympathetic nerve terminals, and the relevance of this system for maintaining macrophages in stages compatible to low-grade inflammation, our data open the possibility that extra-pineal melatonin acts as an autocrine/paracrine signal in macrophages under resolution or tolerant phenotypes. (AU)

Processo FAPESP: 13/13691-1 - Eixo imune-pineal: integrando a biologia do tempo em condições fisiológicas, fisiopatológicas e patológicas
Beneficiário:Regina Pekelmann Markus
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 09/17923-9 - Glândula pineal como alvo do peptídeo b-amilóide
Beneficiário:Erika Cecon
Linha de fomento: Bolsas no Brasil - Doutorado