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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

A brief review about melatonin, a pineal hormone

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Autor(es):
do Amaral, Fernanda Gaspar [1] ; Cipolla-Neto, Jose [2]
Número total de Autores: 2
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo UNIFESP, Dept Fisiol, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Inst Ciencias Biomed, Dept Fisiol & Biofis, Sao Paulo, SP - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo de Revisão
Fonte: ARCHIVES OF ENDOCRINOLOGY METABOLISM; v. 62, n. 4, p. 472-479, JUL-AUG 2018.
Citações Web of Science: 12
Resumo

Melatonin is a ubiquitous molecule in nature, being locally synthesized in several cells and tissues, besides being a hormone that is centrally produced in the pineal gland of vertebrates, particularly in mammals. Its pineal synthesis is timed by the suprachiasmatic nucleus, that is synchronized to the light-dark cycle via the retinohypothalamic tract, placing melatonin synthesis at night, provided its dark. This unique trait turns melatonin into an internal synchronizer that adequately times the organism's physiology to the daily and seasonal demands. Besides being amphiphilic, melatonin presents specific mechanisms and ways of action devoted to its role as a time-giving agent, being widely spread in the organism. The present review aims to focus on melatonin as a pineal hormone with specific mechanisms and ways of action, besides presenting the clinical syndromes related to its synthesis and/or function disruptions. (AU)

Processo FAPESP: 14/50457-0 - Melatonina e a regulação do metabolismo energético: estudos básicos, clínicos e epidemiológicos
Beneficiário:José Cipolla Neto
Linha de fomento: Auxílio à Pesquisa - Temático