Exploring malaria vector diversity on the Amazon Frontier

Autor(es)

Bourke, Brian P. ^[1] ; Conn, Jan E. ^{[2, 3]} ; de Oliveira, Tatiane M. P. ^[1] ; Chaves, Leonardo S. M. ^[1] ; Bergo, Eduardo S. ^[4] ; Laporta, Gabriel Z. ^[5] ; Sallum, Maria A. M. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Publ Hlth, Dept Epidemiol, Sao Paulo, SP - Brazil

^[2] SUNY Albany, Sch Publ Hlth, Dept Biomed Sci, Albany, NY 12222 - USA

^[3] New York State Dept Hlth, Wadsworth Ctr, Slingerlands, NY 12159 - USA

^[4] Secretaria Estado Saude Sao Paulo, Superintendencia Controle Endemias, Araraquara, SP - Brazil

^[5] Fac Med ABC, Setor Posgrad Pesquisa & Inovacao, Santo Andre, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Malaria Journal; v. 17, SEP 27 2018.
• Citações Web of Science: 2

Resumo

Background: Deforestation in the Amazon and the social vulnerability of its settler communities has been associated with increased malaria incidence. The feeding biology of the most important malaria vectors in the region, notably Nyssorhynchus darlingi, compounds efforts to control vectors and reduce transmission of what has become known as ``Frontier Malaria{''}. Exploring Anophelinae mosquito diversity is fundamental to understanding the species responsible for transmission and developing appropriate management and intervention strategies for malaria control in the Amazon River basin. Methods: This study describes Anophelinae mosquito diversity from settler communities affected by Frontier Malaria in the states of Acre, Amazonas and Rondonia by analysing CO/ gene data using cluster and tree-based species delimitation approaches. Results: In total, 270 specimens from collection sites were sequenced and these were combined with 151 reference (GenBank) sequences in the analysis to assist in species identification. Conservative estimates found that the number of species collected at these sites was between 23 (mPTP partition) and 27 (strict ABGD partition) species, up to 13 of which appeared to be new. Nyssorhynchus triannulatus and Nyssorhynchus braziliensis displayed exceptional levels of intraspecific genetic diversity but there was little to no support for putative species complex status. Conclusions: This study demonstrates that Anophelinae mosquito diversity continues to be underestimated in poorly sampled areas where frontier malaria is a major public health concern. The findings will help shape future studies of vector incrimination and transmission dynamics in these areas and support efforts to develop more effective vector control and transmission reduction strategies in settler communities in the Amazon River basin. (AU)

• Processo FAPESP: 14/26229-7 - Genômica de paisagens em gradientes latitudinais e ecologia de Anopheles darlingi
• Beneficiário: Maria Anice Mureb Sallum
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 14/09774-1 - Dinâmica de transmissão de malária em diferentes limiares de fragmentação da paisagem
• Beneficiário: Gabriel Zorello Laporta
• Modalidade de apoio: Auxílio à Pesquisa - Programa BIOTA - Jovens Pesquisadores