Aldosterone infusion into the 4th ventricle produces sodium appetite with baroreflex attenuation independent of renal or blood pressure changes

Autor(es)

Gasparini, S. ^{[1, 2]} ; Melo, M. R. ^[2] ; Andrade-Franze, G. M. F. ^[2] ; Geerling, J. C. ^[1] ; Menani, J. V. ^[2] ; Colombari, E. ^[2]

Afiliação do(s) autor(es)

^[1] Univ Iowa, Dept Neurol, Carver Coll Med, Iowa City, IA 52242 - USA

^[2] Sao Paulo State Univ, UNESP, Sch Dent, Dept Physiol & Pathol, Rua Humaita 1680, BR-14801903 Araraquara, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Brain Research; v. 1698, p. 70-80, NOV 1 2018.
• Citações Web of Science: 1

Resumo

Aldosterone infusion into the 4th ventricle (4th V), upstream the nucleus of the solitary tract (NTS), produces strong 0.3 M NaCl intake. In the present study, we investigated whether aldosterone infusion into the 4th V activates HSD2 neurons, changes renal excretion, or alters blood pressure and cardiovascular reflexes. Chronic infusion of aldosterone (100 ng/h) into the 4th V increased daily 0.3 M NaCl intake (up to 44 +/- 10, vs. vehicle: 5.6 +/- 3.4 ml/24 h) and also c-Fos expression in HSD2 neurons in the NTS and in non-HSD2 neurons in the NTS. Natriuresis, diuresis and positive sodium balance were present in rats that ingested 0.3 M NaCl, however, renal excretion was not modified by 4th V aldosterone in rats that had no access to NaCl. 4th V aldosterone also reduced baroreflex sensitivity (-2.8 +/- 0.5, vs. vehicle: -5.1 +/- 0.9 bpm/mmHg) in animals that had sodium available, without changing blood pressure. The results suggest that sodium intake induced by aldosterone infused into the 4th V is associated with activation of NTS neurons, among them the HSD2 neurons. Aldosterone infused into the 4th V in association with sodium intake also impairs baroreflex sensitivity, without changing arterial pressure. (C) 2018 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 13/00026-0 - Caracterização das ações da aldosterona no tronco cerebral sobre o controle do equilíbrio hidroeletrolítico e regulação cardiovascular
• Beneficiário: Silvia Gasparini
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 15/23467-7 - Fisiopatologia experimental: mecanismos centrais de controle cardiovascular e respiratório envolvidos em modelos experimentais de hipertensão e obesidade
• Beneficiário: Eduardo Colombari
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 18/04134-5 - Efeitos centrais da aldosterona no controle hidrosalino: função dos neurônios HSD2 do NTS e circuitos relacionados
• Beneficiário: Eduardo Colombari
• Modalidade de apoio: Auxílio à Pesquisa - Pesquisador Visitante - Internacional