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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Developmental programming of the female neuroendocrine system by steroids

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Autor(es):
Adriana Abruzzese, Giselle [1] ; Crisosto, Nicolas [2, 3] ; Kempinas, Wilma De Grava [4] ; Sotomayor-Zarate, Ramon [5]
Número total de Autores: 4
Afiliação do(s) autor(es):
[1] Univ Buenos Aires, Lab Fisiopatol Ovar, Ctr Estudios Farmacol & Botanicos CEFYBO, Consejo Nacl Invest Cient & Tecn CONICET, Fac Med, Paraguay 2155, C1121ABG, Buenos Aires, DF - Argentina
[2] Univ Chile, Sch Med, Endocrinol & Metab Lab, West Div, Santiago - Chile
[3] Clin Las Condes, Endocrinol Unit, Santiago - Chile
[4] Univ Estadual Paulista UNESP, Lab Reprod & Dev Biol & Toxicol, Dept Morphol, Inst Biosci, Botucatu, SP - Brazil
[5] Univ Valparaiso, Lab Neuroquim & Neurofarmacol, Ctr Neurobiol & Fisiopatol Integrativa, Inst Fisiol, Fac Ciencias, Valparaiso - Chile
Número total de Afiliações: 5
Tipo de documento: Artigo de Revisão
Fonte: Journal of Neuroendocrinology; v. 30, n. 10, SI OCT 2018.
Citações Web of Science: 2
Resumo

Developmental programming refers to processes that occur during early life that may have long-term consequences, modulating adult health and disease. Complex diseases, such as diabetes, cancer and cardiovascular disease, have a high prevalence in different populations, are multifactorial, and may have a strong environmental component. The environment interacts with organisms, affecting their behaviour, morphology and physiology. This interaction may induce permanent or long-term changes, and organisms may be more susceptible to environmental factors during certain developmental stages, such as the prenatal and early postnatal periods. Several factors have been identified as responsible for inducing the reprogramming of various reproductive and nonreproductive tissues. Among them, both natural and synthetic steroids, such as endocrine disruptors, are known to have either detrimental or positive effects on organisms depending on the dose of exposure, stage of development and biological sexual background. The present review focuses on the action of steroids and endocrine disruptors as agents involved in developmental programming and on their modulation and effects on female neuroendocrine functions. (AU)

Processo FAPESP: 12/25350-1 - Efeitos da exposição in útero à betametasona sobre aspectos reprodutivos de ratos machos, com ênfase na qualidade espermática e fertilidade: uma abordagem multigeracional
Beneficiário:Cibele dos Santos Borges
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 14/13660-1 - Efeitos da exposição in útero à betametasona sobre a instalação da puberdade e aspectos reprodutivos de Ratas Wistar
Beneficiário:Tainá Louise Pacheco
Linha de fomento: Bolsas no Brasil - Iniciação Científica