Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Chronotropic Incompetence and Reduced Heart Rate Recovery in Rheumatoid Arthritis

Texto completo
Autor(es):
Pecanha, Tiago ; Rodrigues, Reynaldo ; Pinto, Ana Jessica ; Sa-Pinto, Ana Lucia ; Guedes, Lissiane ; Bonfiglioli, Karina ; Gualano, Bruno ; Roschel, Hamilton
Número total de Autores: 8
Tipo de documento: Artigo Científico
Fonte: JCR-JOURNAL OF CLINICAL RHEUMATOLOGY; v. 24, n. 7, p. 375-380, OCT 2018.
Citações Web of Science: 0
Resumo

Background/Objective Recent studies have indicated that cardiac autonomic dysfunction is an early sign of cardiovascular impairment in rheumatoid arthritis (RA). Previous studies have mainly focused on resting assessments; however, analysis of heart rate (HR) responses to exercise might provide additional information on cardiac autonomic dysfunction in this disease. Thus, we aimed to assess the HR responses during and after a maximal graded exercise test in patients with RA and healthy controls (CONs). Methods This was a cross-sectional study in which 27 female RA patients and 14 female CONs frequency matched by physical activity, age, and body mass index were compared for HR responses during and after a maximal graded exercise test. Results Rheumatoid arthritis patients showed reduced chronotropic response (94.3% 16.3% vs. 106.1% +/- 10.3%, p = 0.02) and lower HR recovery (HRR) at 30 seconds (8.6 +/- 6.7 vs. 13.4 +/- 5.2 beats/min {[}bpm], p = 0.02), 60 seconds (16.5 +/- 7.8 vs. 24.0 +/- 9.9 bpm, p = 0.01), 120 seconds (32.6 +/- 9.9 vs. 40.7 +/- 12.3 bpm, p = 0.03), and 180 seconds (46.5 +/- 12.6 vs. 55.5 +/- 13.4 bpm, p = 0.05) post-maximal exercise test when compared with CONs. Moreover, the prevalence of chronotropic incompetence (i.e., failure to reach 80% of the HR-predicted response) and abnormal HRR (i.e., HRR 12 bpm) were, respectively, 22.2% and 37.1% in RA patients. Conclusions Patients with RA showed reduced chronotropic response to exercise and slower postexercise HRR. These abnormal autonomic responses to exercise indicate the presence of cardiac autonomic dysfunction and increased cardiovascular risk in this population. (AU)

Processo FAPESP: 15/26937-4 - Estudos sobre (in)atividade física em pacientes com artrite reumatóide: caracterização, associações com a doença e efeitos da interrupção do tempo sedentário
Beneficiário:Ana Jéssica Pinto
Linha de fomento: Bolsas no Brasil - Doutorado Direto
Processo FAPESP: 16/23319-0 - Disfunção autonômica cardiovascular em pacientes com artrite reumatoide: caracterização, associações com a doença e efeitos da interrupção do tempo sedentário
Beneficiário:Tiago Peçanha de Oliveira
Linha de fomento: Bolsas no Brasil - Pós-Doutorado